Evidence map›Paper›PMID 31594949›Full record

SynthesisNature communications2019

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Caroline M Nievergelt, Adam X Maihofer, Torsten Klengel, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Shareefa Dalvie, Laramie E Duncan, Joel Gelernter and 169 more

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03170362 (PRIME Care), which is not on this map. Cited by 376 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 13 pooled it
48.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03170362 nacompletednot on this map

PRIME Care (PRecision Medicine In MEntal Health Care)

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2022Enrolled1,944ConditionsMajor DepressionArmsPharmacogenetic Test
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 13 syntheses or guidelines pooled it, 667 citations in OpenAlex.

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  12. Post-Traumatic Stress Disorder and Risk of Degenerative Synucleinopathies: Systematic Review and Meta-Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Pooled it
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  17. Genetic interconnections between personality-related phenotypes and psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026
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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

179 authors at 20 institutions in 11 countries.

Caroline M NievergeltUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA. cnievergelt@ucsd.edu.ORCID http://orcid.org/0000-0001-5766-8923
Adam X MaihoferUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4517-1623
Torsten KlengelHarvard Medical School, Department of Psychiatry, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7045-9229
Elizabeth G AtkinsonBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6308-776X
Chia-Yen ChenBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9548-5597
Karmel W ChoiBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3914-2431
Jonathan R I ColemanKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, GB, USA.ORCID http://orcid.org/0000-0002-6759-0944
Shareefa DalvieUniversity of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.
Laramie E DuncanStanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1131-661X
Joel GelernterUS Department of Veterans Affairs, Department of Psychiatry, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Daniel F LeveyVA Connecticut Healthcare Center, West Haven, CT, USA.ORCID http://orcid.org/0000-0001-8431-9569
Mark W LogueVA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Renato PolimantiVA Connecticut Healthcare Center, West Haven, CT, USA.
Allison C ProvostCohen Veterans Bioscience, Cambridge, MA, USA.
Andrew RatanatharathornHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9855-0438
Murray B SteinUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Katy TorresUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4201-0349
Allison E AielloGillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, USA.
Lynn M AlmliEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4399-807X
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Søren B AndersenThe Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Sjaelland, Denmark.
Ole A AndreassenUniversity of Oslo, Institute of Clinical Medicine, Oslo, NO, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Paul A ArbisiMinneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.
Allison E Ashley-KochDuke University, Duke Molecular Physiology Institute, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5409-9155
S Bryn AustinHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Esmina AvdibegovicUniversity Clinical Center of Tuzla, Department of Psychiatry, Tuzla, BA, Bosnia and Herzegovina.
Dragan BabićUniversity Clinical Center of Mostar, Department of Psychiatry, Mostar, BA, Bosnia and Herzegovina.
Marie Bækvad-HansenStatens Serum Institut, Department for Congenital Disorders, Copenhagen, DK, Denmark.
Dewleen G BakerUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1736-9838
Jean C BeckhamDurham VA Medical Center, Research, Durham, NC, USA.
Laura J BierutWashington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Jonathan I BissonCardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK.
Marco P BoksUMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, Utrecht, NL, Netherlands.ORCID http://orcid.org/0000-0001-6163-7484
Elizabeth A BolgerHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Bekh BradleyEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Megan BrashearLouisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-7693-6775
Gerome BreenKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, GB, USA.ORCID http://orcid.org/0000-0003-2053-1792
Richard A BryantUniversity of New South Wales, Department of Psychology, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9607-819X
Angela C BustamanteUniversity of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8016-1733
Jonas Bybjerg-GrauholmStatens Serum Institut, Department for Congenital Disorders, Copenhagen, DK, Denmark.ORCID http://orcid.org/0000-0003-1705-4008
Joseph R CalabreseUniversity Hospitals, Department of Psychiatry, Cleveland, OH, USA.
José M Caldas-de-AlmeidaCEDOC -Chronic Diseases Research Centre, Lisbon Institute of Global Mental Health, Lisbon, PT, Portugal.ORCID http://orcid.org/0000-0003-1902-6772
Anders M DaleUniversity of California San Diego, Department of Radiology, Department of Neurosciences, La Jolla, CA, USA.
Mark J DalyMassachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.ORCID http://orcid.org/0000-0002-0949-8752
Nikolaos P DaskalakisHarvard Medical School, Department of Psychiatry, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1660-9112
Jürgen DeckertUniversity Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany.
Douglas L DelahantyKent State University, Department of Psychological Sciences, Kent, OH, USA.ORCID http://orcid.org/0000-0002-9021-7064
Michelle F DennisDurham VA Medical Center, Research, Durham, NC, USA.
Seth G DisnerMinneapolis VA Health Care System, Research Service Line, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3635-9421
Katharina DomschkeMedical Center-University of Freiburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Freiburg, DE, Germany.
Alma Dzubur-KulenovicUniversity Clinical Center of Sarajevo, Department of Psychiatry, Sarajevo, BA, Bosnia and Herzegovina.ORCID http://orcid.org/0000-0002-1883-7111
Christopher R ErbesUniversity of Minnesota, Department of Psychiatry, Minneapolis, MN, USA.
Alexandra EvansCardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Lindsay A FarrerBoston University School of Medicine, Department of Medicine, Boston, MA, USA.
Norah C FeenyCase Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-8590-4591
Janine D FloryIcahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.
David ForbesUniversity of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA.
Carol E FranzUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Sandro GaleaBoston University, Department of Psychological and Brain Sciences, Boston, MA, USA.
Melanie E GarrettDuke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Bizu GelayeHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7934-548X
Elbert GeuzeNetherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht, Utrecht, NL, Netherlands.ORCID http://orcid.org/0000-0003-3479-2379
Charles GillespieEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-5476-5920
Aferdita Goci UkaUniversity Clinical Centre of Kosovo, Department of Psychiatry, Prishtina, Kosovo, XK, USA.
Scott D GordonQIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7623-328X
Guia GuffantiHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Rasha HammamiehUS Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.
Supriya HarnalBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Michael A HauserDuke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2667-5420
Andrew C HeathWashington University in Saint Louis School of Medicine, Department of Genetics, Saint Louis, MO, USA.
Sian M J HemmingsStellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.
David Michael HougaardStatens Serum Institut, Department for Congenital Disorders, Copenhagen, DK, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Miro JakovljevicUniversity Hospital Center of Zagreb, Department of Psychiatry, Zagreb, HR, USA.
Marti JettUS Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.ORCID http://orcid.org/0000-0002-2899-0216
Eric Otto JohnsonRTI International, Behavioral Health and Criminal Justice Division, Research Triangle Park, NC, USA.
Ian JonesCardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.ORCID http://orcid.org/0000-0001-5821-5889
Tanja JovanovicEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Xue-Jun QinDuke University, Duke Molecular Physiology Institute, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9169-253X
Angela G JunglenKent State University, Department of Psychological Sciences, Kent, OH, USA.
Karen-Inge KarstoftThe Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Sjaelland, Denmark.ORCID http://orcid.org/0000-0001-9234-9784
Milissa L KaufmanHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Ronald C KesslerHarvard Medical School, Department of Psychiatry, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4831-2305
Alaptagin KhanMcLean Hospital, Belmont, MA, USA.
Nathan A KimbrelDuke University, Duke Molecular Physiology Institute, Durham, NC, USA.
Anthony P KingUniversity of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA.
Nastassja KoenUniversity of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.
Henry R KranzlerUniversity of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA.
William S KremenUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Bruce R LawfordQueensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, AU, Australia.
Lauren A M LeboisHarvard Medical School, Department of Psychiatry, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5816-9181
Catrin E LewisCardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Sarah D LinnstaedtUNC Institute for Trauma Recovery, Department of Anesthesiology, Chapel Hill, NC, USA.
Adriana LoriEmory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA.
Bozo LugonjaCardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Jurjen J LuykxUMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, Utrecht, NL, Netherlands.ORCID http://orcid.org/0000-0002-6439-2774
Michael J LyonsBoston University, Dean's Office, Boston, MA, USA.
Jessica Maples-KellerEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Charles MarmarNew York University School of Medicine, Department of Psychiatry, New York, NY, USA.
Alicia R MartinBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0241-3522
Nicholas G MartinQIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Douglas MaurerUnited States Army, Command, Fort Sill, OK, USA.
Matig R MavissakalianUniversity Hospitals, Department of Psychiatry, Cleveland, OH, USA.
Alexander McFarlaneUniversity of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia.
Regina E McGlincheyVA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA.
Katie A McLaughlinHarvard University, Department of Psychology, Boston, MA, USA.
Samuel A McLeanUNC Institute for Trauma Recovery, Department of Anesthesiology, Chapel Hill, NC, USA.
Sarah McLeayGallipoli Medical Research Institute, PTSD Initiative, Greenslopes, Queensland, AU, Australia.
Divya MehtaQueensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, AU, Australia.
William P MilbergVA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA.
Mark W MillerVA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6393-8563
Rajendra A MoreyDuke University, Duke Molecular Physiology Institute, Durham, NC, USA.
Charles Phillip MorrisQueensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, AU, Australia.ORCID http://orcid.org/0000-0001-8976-619X
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Preben B MortensenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Benjamin M NealeBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1513-6077
Elliot C NelsonWashington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Sonya B NormanUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4751-1882
Meaghan O'DonnellUniversity of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA.ORCID http://orcid.org/0000-0003-4349-0022
Holly K OrcuttNorthern Illinois University, Department of Psychology, DeKalb, IL, USA.
Matthew S PanizzonUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Edward S PetersLouisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Alan L PetersonUniversity of Texas Health Science Center at San Antonio, Department of Psychiatry, San Antonio, TX, USA.
Matthew PeverillUniversity of Washington, Department of Psychology, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8257-1004
Robert H PietrzakYale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Melissa A PolusnyUniversity of Minnesota, Department of Psychiatry, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-4932-305X
John P RiceWashington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Stephan RipkeBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Victoria B RisbroughUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8347-3820
Andrea L RobertsHarvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5023-4399
Alex O RothbaumCase Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA.
Barbara O RothbaumEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Peter Roy-ByrneUniversity of Washington, Department of Psychology, Seattle, WA, USA.
Ken RuggieroMedical University of South Carolina, Department of Nursing and Department of Psychiatry, Charleston, SC, USA.
Ariane RungLouisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Bart P F RuttenMaastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, Limburg, NL, Netherlands.
Nancy L SacconeWashington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Sixto E SanchezUniversidad Peruana de Ciencias Aplicadas Facultad de Ciencias de la Salud, Department of Medicine, Lima, Lima, PE, USA.
Dick SchijvenUMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, Utrecht, NL, Netherlands.ORCID http://orcid.org/0000-0001-5190-7241
Soraya SeedatStellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.ORCID http://orcid.org/0000-0002-5118-786X
Antonia V SeligowskiHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Julia S SengUniversity of Michigan, School of Nursing, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7066-6348
Christina M SheerinVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.ORCID http://orcid.org/0000-0003-3773-641X
Derrick SiloveUniversity of New South Wales, Department of Psychiatry, Sydney, NSW, AU, USA.
Alicia K SmithEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8537-5156
Jordan W SmollerBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334
Scott R SponheimMinneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2782-0856
Dan J SteinUniversity of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.ORCID http://orcid.org/0000-0001-7218-7810
Jennifer S StevensEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4674-0314
Jennifer A SumnerColumbia University Medical Center, Department of Medicine, New York, NY, USA.
Martin H TeicherHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Wesley K ThompsonUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Edward TrapidoLouisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Monica UddinUniversity of South Florida College of Public Health, Genomics Program, Tampa, FL, USA.
Robert J UrsanoUniformed Services University, Department of Psychiatry, Bethesda, Maryland, USA.
Leigh Luella van den HeuvelStellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.
Miranda Van HooffUniversity of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia.
Eric VermettenNew York University School of Medicine, Department of Psychiatry, New York, NY, USA.
Christiaan H VinkersAmsterdam UMC (location VUmc), Department of Anatomy and Neurosciences, Amsterdam, Holland, NL, Netherlands.ORCID http://orcid.org/0000-0003-3698-0744
Joanne VoiseyQueensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, AU, Australia.ORCID http://orcid.org/0000-0001-6645-6164
Yunpeng WangThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.ORCID http://orcid.org/0000-0001-9831-1090
Zhewu WangRalph H Johnson VA Medical Center, Department of Mental Health, Charleston, SC, USA.
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Michelle A WilliamsHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5807-5281
Douglas E WilliamsonDurham VA Medical Center, Research, Durham, NC, USA.
Sherry WinternitzHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Christiane WolfUniversity Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany.
Erika J WolfVA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Jonathan D WolffMcLean Hospital, Belmont, MA, USA.
Rachel YehudaIcahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.
Ross McD YoungQueensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, AU, Australia.
Keith A YoungBaylor Scott and White Central Texas, Department of Psychiatry, Temple, TX, USA.ORCID http://orcid.org/0000-0001-6060-3573
Hongyu ZhaoYale University, Department of Biostatistics, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1195-9607
Lori A ZoellnerUniversity of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA.
Israel LiberzonUniversity of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA.
Kerry J ResslerHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Magali HaasCohen Veterans Bioscience, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6611-2449
Karestan C KoenenBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Harvard University · USUniversity of California San Diego · USBroad Institute · USDuke University · USEmory University · USQueensland University of Technology · AUVA Boston Healthcare System · USWashington University in St. Louis · USLouisiana State University Health Sciences Center New Orleans · USUniversity Medical Center Utrecht · NLUniversity of Michigan · USBoston University · USStatens Serum Institut · DKUniversity of Minnesota · USUniversity of Washington · USWestern Cape Department of Health · ZAYale University · USAarhus University · DKCase Western Reserve University · USCohen Veterans Bioscience · US

Funding

Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Epigenomic Predictors of PTSD and Traumatic Stress in an African American CohortR01MD011728 · NIMHD · UNIVERSITY OF SOUTH FLORIDA · PI AIELLO, ALLISON E, UDDIN, MONICA · 2017 to 2025
$5.7M
2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M
4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M, SEBAT, JONATHAN · 2021 to 2025
$2.1M
Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679k
Neurobiology of Traumatic Dissociation in a Transdiagnostic Study of Women with Childhood MaltreatmentR21MH112956 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2017 to 2018
$446k
Neurobiology of Self-Referential Processing in Posttraumatic Stress Disorder Dysfunction and RecoveryF32MH109274 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2016 to 2018
$174k
Polygenic predictors of the neural and clinical correlates of TBI and PTSDIK1RX002325 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI DISNER, SETH GORDON · 2017 to 2018
–
Exploring polygenic risk as a means for personalizing TBI rehabilitationIK2RX002922 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI DISNER, SETH GORDON · 2019 to 2024
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BLRD VA I01 BX002558Medical Research Council MR/L010305/1NIMHD NIH HHS R01 MD011728NIMH NIH HHS F32 MH109274NIMH NIH HHS K01 MH118467NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH124847NIMH NIH HHS R21 MH112956NIMH NIH HHS T32 MH017119NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539RRD VA IK1 RX002325RRD VA IK2 RX002922
6 · The paper itself

Abstract

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.

Indexed as

Genetic LociGenetic Predisposition to DiseaseBlack PeopleDatasets as TopicFemaleGenome-Wide Association StudyHumansMaleSex FactorsStress Disorders, Post-TraumaticUbiquitin-Protein LigasesVeteransWhite Peopleparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID31594949
PMCPMC6783435
OpenAlexW2979994192

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