Evidence map›Paper›PMID 31594932›Full record

ArticleNature communications2019

Upconversion superballs for programmable photoactivation of therapeutics.

Zhen Zhang, Muthu Kumara Gnanasammandhan Jayakumar, Xiang Zheng, Swati Shikha, Yi Zhang, Akshaya Bansal, Dennis J J Poon, Pek Lim Chu, Eugenia L L Yeo, Melvin L K Chua and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 138 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhen ZhangFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Muthu Kumara Gnanasammandhan JayakumarFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Xiang ZhengFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Swati ShikhaFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Yi ZhangFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Akshaya BansalFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Dennis J J PoonDivision of Radiation Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.
Pek Lim ChuOncology Academic Program, Duke-NUS Medical School, Singapore, 169857, Singapore.
Eugenia L L YeoDivision of Medical Sciences, National Cancer Centre Singapore, Singapore, 169610, Singapore.
Melvin L K ChuaDivision of Radiation Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.ORCID http://orcid.org/0000-0002-1648-1473
Soo Khee CheeOncology Academic Program, Duke-NUS Medical School, Singapore, 169857, Singapore.
Yong ZhangFaculty of Engineering, Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore. biezy@nus.edu.sg.ORCID http://orcid.org/0000-0002-1303-0458
National University of Singapore · SGDuke-NUS Medical School · SGNational Cancer Centre Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upconversion nanoparticles (UCNPs) are the preferred choice for deep-tissue photoactivation, owing to their unique capability of converting deep tissue-penetrating near-infrared light to UV/visible light for photoactivation. Programmed photoactivation of multiple molecules is critical for controlling many biological processes. However, syntheses of such UCNPs require epitaxial growth of multiple shells on the core nanocrystals and are highly complex/time-consuming. To overcome this bottleneck, we have modularly assembled two distinct UCNPs which can individually be excited by 980/808 nm light, but not both. These orthogonal photoactivable UCNPs superballs are used for programmed photoactivation of multiple therapeutic processes for enhanced efficacy. These include sequential activation of endosomal escape through photochemical-internalization for enhanced cellular uptake, followed by photocontrolled gene knockdown of superoxide dismutase-1 to increase sensitivity to reactive oxygen species and finally, photodynamic therapy under these favorable conditions. Such programmed activation translated to significantly higher therapeutic efficacy in vitro and in vivo in comparison to conventional, non-programmed activation.

Indexed as

AnimalsCalcium CompoundsCell Line, TumorCell Membrane PermeabilityDrug CarriersDrug DesignEndosomesGene Knockout TechniquesHeLa CellsHumansIndolesInfrared RaysIsoindolesMiceNanoparticlesNeoplasmsCalcium Compoundscalcium silicateDrug CarriersIndolesIsoindolesOrganometallic CompoundsPhotosensitizing AgentsRNA, Small InterferingSilicatesSOD1 protein, humanSuperoxide Dismutase-1Zinc CompoundsZn(II)-phthalocyanine

Identifiers

PMID31594932
PMCPMC6783568
OpenAlexW2979770344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.