ArticleNature communications2019
Insights into the ecological roles and evolution of methyl-coenzyme M reductase-containing hot spring Archaea.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 162 citations in OpenAlex.
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- Unveiling the life of archaea in sediments: Diversity, metabolic potentials, and ecological roles.iMetaOmics · 2025Review
- Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle.Nature communications · 2025Article
- Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes.Scientific data · 2025Article
- A metagenomic perspective on the microbial prokaryotic genome census.Science advances · 2025Article
- Back flux during anaerobic oxidation of butane support archaea-mediated alkanogenesis.Nature communications · 2024Article
- Insights into chemoautotrophic traits of a prevalent bacterial phylum CSP1-3, hereinNational science review · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages. Here, we study the mcr-containing archaeal MAGs from several hot springs, which reveal further expansion in the diversity of archaeal organisms performing methane/alkane metabolism. Significantly, an MAG basal to organisms from the phylum Thaumarchaeota that contains mcr genes, but not those for ammonia oxidation or aerobic metabolism, is identified. Together, our phylogenetic analyses and ancestral state reconstructions suggest a mostly vertical evolution of mcrABG genes among methanogens and methanotrophs, along with frequent horizontal gene transfer of mcr genes between alkanotrophs. Analysis of all mcr-containing archaeal MAGs/genomes suggests a hydrothermal origin for these microorganisms based on optimal growth temperature predictions. These results also suggest methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor.
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