Evidence map›Paper›PMID 31594908›Full record

ReviewGenetics2019

TOR Signaling in

T Keith Blackwell, Aileen K Sewell, Ziyun Wu, Min Han

Open access · greenAbstract readReview
In one paragraph

Review in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 153 citations in OpenAlex.

  1. Article
  2. Article
  3. Autophagy: A Double-Edged Sword in the Aging ofInternational journal of molecular sciences · 2026
    Review
  4. Article
  5. microPublication biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Developing Endogenous Autophagy Reporters inInternational journal of molecular sciences · 2025
    Article
  10. Lactate promotes longevity through redox-driven lipid remodeling inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Autophagy activator AA-20 improves proteostasis and extendsProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Hyperactivation of mTORC1 by an endogenousmicroPublication biology · 2025
    Article
  20. Journal of biosciences · 2025
    Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

T Keith BlackwellResearch Division, Joslin Diabetes Center, Department of Genetics, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts keith.blackwell@joslin.harvard.edu mhan@colorado.edu.
Aileen K SewellDepartment of MCDB, University of Colorado at Boulder, and.
Ziyun WuResearch Division, Joslin Diabetes Center, Department of Genetics, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts.
Min HanDepartment of MCDB, University of Colorado at Boulder, and keith.blackwell@joslin.harvard.edu mhan@colorado.edu.
Harvard University · USHoward Hughes Medical Institute · USJoslin Diabetes Center · USUniversity of Colorado Boulder · US

Funding

RAS MEDIATED SIGNAL TRANSDUCTION IN C. ELEGANSR01GM047869 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI HAN, MIN · 1992 to 2020
$5.0M
Signaling mechanisms that detect stress and maintain homeostasis - Research Supplement to Promote Diversity in Health-Related ResearchR35GM122610 · NIGMS · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2017 to 2025
$4.7M
Uncovering Conserved Lipid Homeostasis Mechanisms that Mediate Longevity after Germ Cell Loss in C. ElegansR01AG054215 · NIA · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 2017 to 2026
$3.9M
Mechanism by which fatty acid metabolism impacts muscle maintenanceR01AR074503 · NIAMS · UNIVERSITY OF COLORADO · PI HAN, MIN · 2019 to 2023
$1.7M
Howard Hughes Medical InstituteNIAMS NIH HHS R01 AR074503NIA NIH HHS R01 AG054215NIGMS NIH HHS R01 GM047869NIGMS NIH HHS R35 GM122610
6 · The paper itself

Abstract

The

Indexed as

AgingAnimalsCaenorhabditis elegansHumansLongevitySignal TransductionTOR Serine-Threonine KinasesTranscription FactorsTOR Serine-Threonine KinasesTranscription FactorsagingCaenorhabditis elegans developmentDAF-15growth regulationmetabolismNprl2NPRL-2Nprl3NPRL-3nutrient signalingRagARAGA-1RagCRaptorRhebRheb-1RictorRSKS-1S6 kinasesphingolipidTORTORC1TORC2WormBook

Identifiers

PMID31594908
PMCPMC6781902
OpenAlexW2980060208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.