Evidence map›Paper›PMID 31594844›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Fitness effects but no temperature-mediated balancing selection at the polymorphic

Mohammad A Siddiq, Joseph W Thornton

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  9. Ethanol resistance inEcology and evolution · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mohammad A SiddiqDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637.
Joseph W ThorntonDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637; joet1@uchicago.edu.
University of Chicago · US

Funding

PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Mechanisms for the evolution of novel DNA specificity in a transcription factor fR01GM104397 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2013 to 2016
$1.3M
Deep characterization of the sequence space and evolutionary trajectories of reconstructed ancestral proteins - Resubmission 01R01GM121931 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2017 to 2020
$1.3M
NHGRI NIH HHS T32 HG000040NIGMS NIH HHS R01 GM104397NIGMS NIH HHS R01 GM121931NIGMS NIH HHS T32 GM007197
6 · The paper itself

Abstract

Polymorphism in the alcohol dehydrogenase (ADH) protein of

Indexed as

Alcohol DehydrogenaseAllelesAnimalsAnimals, Genetically ModifiedDrosophila melanogasterDrosophila ProteinsEthanolPolymorphism, GeneticTemperatureADH protein, DrosophilaAlcohol DehydrogenaseDrosophila ProteinsEthanolactivity/stability trade-offadaptationalcohol physiologyevolutionary biochemistryevolutionary genetics

Identifiers

PMID31594844
PMCPMC6815130
OpenAlexW2980119150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.