ArticleLife science alliance2019
Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish.
Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Regulation of the lncRNANAR molecular medicine · 2025Article
- Article
- Epithelial-mesenchymal transition in tissue repair and degeneration.Nature reviews. Molecular cell biology · 2024Review
- Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina.Development (Cambridge, England) · 2024Article
- New insights on the role of microRNAs in retinal Müller glial cell function.The British journal of ophthalmology · 2024Review
- Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration.Frontiers in cell and developmental biology · 2023Review
- The regeneration-responsive elementFrontiers in molecular neuroscience · 2023Article
- Probing cell identity hierarchies by fate titration and collision during direct reprogramming.Molecular systems biology · 2022Article
- Multiplexed genome regulation in vivo with hyper-efficient Cas12a.Nature cell biology · 2022Article
- Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1-Induced OCT4/Nanog Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Molecular Markers of Adult Neurogenesis in the Telencephalon and Tectum of Rainbow Trout,International journal of molecular sciences · 2022Article
- Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.Frontiers in cell and developmental biology · 2022Article
- Retina regeneration: lessons from vertebrates.Oxford open neuroscience · 2022Review
- Conservation of Zebrafish MicroRNA-145 and Its Role during Neural Crest Cell Development.Genes · 2021Article
- Gene alteration in zebrafish exposed to a mixture of substances of abuse.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Müller Glia-Mediated Retinal Regeneration.Molecular neurobiology · 2021Review
- Review
- Differential Regenerative Capacity of the Optic Tectum of Adult Medaka and Zebrafish.Frontiers in cell and developmental biology · 2021Article
- Protective Role of microRNA-200a in Diabetic Retinopathy Through Downregulation of PDLIM1.Journal of inflammation research · 2021Article
- Reprogramming Müller Glia to Regenerate Retinal Neurons.Annual review of vision science · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Octamer-binding transcription factor 4 (Oct4, also known as Pou5F3) is an essential pluripotency-inducing factor, governing a plethora of biological functions during cellular reprogramming. Retina regeneration in zebrafish involves reprogramming of Müller glia (MG) into a proliferating population of progenitors (MGPCs) with stem cell-like characteristics, along with up-regulation of pluripotency-inducing factors. However, the significance of Oct4 during retina regeneration remains elusive. In this study, we show an early panretinal induction of Oct4, which is essential for MG reprogramming through the regulation of several regeneration-associated factors such as Ascl1a, Lin28a, Sox2, Zeb, E-cadherin, and various miRNAs, namely,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.