Evidence map›Paper›PMID 31594821›Full record

ArticlemBio2019

Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between

Catherine J Mitran, Angie Mena, Sedami Gnidehou, Shanna Banman, Eliana Arango, Barbara A S Lima, Hazel Lugo, Aravindhan Ganesan, Ali Salanti, Anthony K Mbonye and 8 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  12. Frontiers in immunology · 2022
    Review
  13. Bio-protocol · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 6 countries.

Catherine J MitranSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada mitran@ualberta.ca.ORCID 0000-0002-8433-0466
Angie MenaSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Sedami GnidehouDepartment of Biology, Campus Saint-Jean University of Alberta, Edmonton, Alberta, Canada.
Shanna BanmanSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Eliana ArangoGrupo Salud y Comunidad, Facultad de Medicina, Medellín, Antioquia, Colombia.
Barbara A S LimaFundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Hazel LugoSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Aravindhan GanesanFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Ali SalantiDepartment of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.
Anthony K MbonyeSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Francis NtumngiaCollege of Public Health, University of South Florida, Tampa, Florida, USA.ORCID 0000-0001-9867-3534
Khaled BarakatFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
John H AdamsCollege of Public Health, University of South Florida, Tampa, Florida, USA.
Flora S KanoFundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Luzia H CarvalhoFundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Amanda E MaestreGrupo Salud y Comunidad, Facultad de Medicina, Medellín, Antioquia, Colombia.
Michael F GoodInstitute for Glycomics, Griffith University, Southport, Queensland, Australia.
Stephanie K YanowSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
University of Alberta · CAFundação Oswaldo Cruz · BRUniversity of South Florida · USGriffith University · AUMakerere University · UGUniversity of Copenhagen · DK

Funding

Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
CIHR RES0016099NIEHS NIH HHS R01 ES016099
6 · The paper itself

Abstract

Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies. In

Indexed as

Immunity, HeterologousAnimalsAntibodies, ProtozoanAntigens, ProtozoanBrazilCell AdhesionChondroitin SulfatesColombiaCross ReactionsEpitope MappingEpitopesHumansMalaria, FalciparumMalaria, VivaxMicePlasmodium falciparumAntibodies, ProtozoanAntigens, ProtozoanChondroitin SulfatesDuffy antigen binding protein, PlasmodiumEpitopesProtozoan ProteinsReceptors, Cell SurfaceVAR2CSA protein, Plasmodium falciparumVirulence Factorscross-speciescryptic epitopesepitopesfalciparumheterologous immunitymalariaPlasmodiumPlasmodium falciparumPlasmodium vivaxpregnancyPvDBPVAR2CSAvivax

Identifiers

PMID31594821
PMCPMC6786876
OpenAlexW2979353094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.