ArticleDrug metabolism and disposition: the biological fate of chemicals2019
Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using
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In one paragraph
Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Naphthalene-DNA Adduct Formation in a Lung Airway Explant Model: The Role of Bioactivation and Naphthalene Metabolites.Chemical research in toxicology · 2026Article
- Naphthalene: MAK Value Documentation, addendum - Translation of the German version from 2022.The MAK collection for occupational health and safety · 2025Article
- Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology.Drug metabolism and disposition: the biological fate of chemicals · 2023Article
- In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Assessing cytochrome P450 function using genetically engineered mouse models.Advances in pharmacology (San Diego, Calif.) · 2022Review
- INTEDE: interactome of drug-metabolizing enzymes.Nucleic acids research · 2021Article
- Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Nataliia KovalchukDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Qing-Yu ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Jacklyn KeltyDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.).
Laura Van WinkleDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.) lsvanwinkle@ucdavis.edu.
Xinxin DingDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (N.K., Q.-Y.Z., X.D.); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York (N.K., Q.-Y.Z.); Center for Health and the Environment, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California (J.K., L.V.W.); and College of Nanoscale Science, State University of New York Polytechnic Institute, Albany, New York (X.D.) xding@pharmacy.arizona.edu.
New York State Department of Health · USSUNY Polytechnic Institute · USUniversity of Arizona · USUniversity of California, Davis · US
Funding
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7MUC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0MTRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1MMetabolic Mechanisms of Naphthalene Toxicity in LungR01ES020867 · NIEHS · WADSWORTH CENTER · PI Xinxin Ding, Laura S Van Winkle · 2013 to 2026
$6.4MNHLBI NIH HHS T32 HL007013NIEHS NIH HHS P30 ES006694NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES020867
Abstract
Previous studies using
Indexed as
AnimalsAryl Hydrocarbon HydroxylasesBiological AvailabilityCytochrome P450 Family 2FemaleHumansInhalation ExposureLiverLungMaleMiceMice, KnockoutMice, TransgenicNaphthalenesTissue DistributionToxicokineticsAryl Hydrocarbon HydroxylasesCYP2A13 protein, humanCYP2F1 protein, humanCytochrome P450 Family 2naphthaleneNaphthalenes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.