ArticleThe Journal of pharmacology and experimental therapeutics2020
A Novel G Protein-Biased Agonist at the
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Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
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- Identification of Subtype-Selective Binding Sites in the Opioid Receptor Family.Journal of chemical information and modeling · 2026Article
- Mechanistic insights into the therapeutic properties of delta opioid receptor.Science advances · 2026Article
- Delta opioid receptors: Overlooked outlier or the next big thing.Current opinion in pharmacology · 2025Review
- Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.CNS drugs · 2025Review
- Structure-guided design of partial agonists at an opioid receptor.Nature communications · 2025Article
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Cryo-EM structure of small-molecule agonist bound delta opioid receptor-GNature communications · 2024Article
- Design, Synthesis, andACS pharmacology & translational science · 2024Article
- Structure-Guided Design of Partial Agonists at an Opioid Receptor.Research square · 2024Article
- Identification of 1,3,8-Triazaspiro[4.5]Decane-2,4-Dione Derivatives as a NovelThe Journal of pharmacology and experimental therapeutics · 2024Article
- Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach.PloS one · 2024Article
- Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide.Molecules (Basel, Switzerland) · 2023Article
- Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures.Neuropharmacology · 2023Review
- State and Future Science of Opioids and Potential of Biased-ligand Technology in the Management of Acute Pain After Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2023Review
- δ-Opioid receptors in primary sensory neurons tonically restrain nociceptive input in chronic pain but do not enhance morphine analgesic tolerance.Neuropharmacology · 2022Article
- Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Experimental considerations for the assessment of in vivo and in vitro opioid pharmacology.Pharmacology & therapeutics · 2022Review
- Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions.Frontiers in pharmacology · 2022Article
- Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Alexandra E ConibearSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Junaid AsgharSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Rob HillSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Graeme HendersonSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Eva BorbelySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Valeria TekusSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Zsuzsanna HelyesSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Josephine PalandriSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Chris BaileySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Ingemar StarkeSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Bengt von MentzerSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
David KendallSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.).
Eamonn KellySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, United Kingdom (A.E.C., R.H., G.H., E.K.); Faculty of Pharmacy, Gomal University, Khyber Pakhtunkhwa, Pakistan (J.A.); PharmInVivo Ltd., Szentagothai Research Centre, Centre for Neuroscience and Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary (E.B., V.T., Z.H.); Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom (J.P., C.B.); and PharmNovo AB, Kungshamn, Sweden (I.S., B.v.M., D.K.) E.Kelly@bristol.ac.uk.
University of Bristol · GBGomal University · PKUniversity of Bath · GBUniversity of Pecs · HU
Funding
Medical Research Council MR/N020669/1
Abstract
Agonists at the
Indexed as
Analgesics, OpioidAnimalsAntidepressive AgentsArrestinBenzamidesChronic PainDrug ToleranceGTP-Binding ProteinsHEK293 CellsHumansMaleMiceModels, AnimalRats, WistarReceptors, Opioid, deltaTreatment OutcomeAnalgesics, OpioidAntidepressive AgentsArrestinbenzamideBenzamidesGTP-Binding ProteinsReceptors, Opioid, delta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.