Evidence map›Paper›PMID 31594422›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Vasodilator effects of sulforaphane in cerebral circulation: A critical role of endogenously produced hydrogen sulfide and arteriolar smooth muscle K

Helena Parfenova, Jianxiong Liu, Daniel T Hoover, Alex L Fedinec

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. KFrontiers in neurology · 2024
    Pooled it
  2. Review
  3. Brassinin Induces HMolecules (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Role of hydrogen sulfide in subarachnoid hemorrhage.CNS neuroscience & therapeutics · 2022
    Review
  9. HInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Helena ParfenovaDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Jianxiong LiuDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Daniel T HooverDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Alex L FedinecDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
University of Tennessee Health Science Center · US

Funding

PERMISSIVE ROLE OF PGI-2 IN NEWBORN CEREBRAL CIRCULATIONR01HL042851 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 1991 to 2019
$3.4M
Endothelial Vasoprotection by HypothermiaR01NS105655 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 2018 to 2022
$2.1M
Astrocyte functions in neonatal brainR01NS101717 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 2017 to 2020
$1.3M
NHLBI NIH HHS R01 HL042851NINDS NIH HHS R01 NS101717NINDS NIH HHS R01 NS105655
6 · The paper itself

Abstract

We investigated the effects of sulforaphane (SFN), an isothiocyanate from cruciferous vegetables, in the regulation of cerebral blood flow using cranial windows in newborn pigs. SFN administered topically (10 µM-1 mM) or systemically (0.4 mg/kg ip) caused immediate and sustained dilation of pial arterioles concomitantly with elevated H

Indexed as

AnimalsAnimals, NewbornArteriolesBrainCerebrovascular CirculationCystathionine beta-SynthaseCystathionine gamma-LyaseEnzyme InhibitorsFemaleHydrogen SulfideIsothiocyanatesKATP ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleCystathionine beta-SynthaseCystathionine gamma-LyaseEnzyme InhibitorsHydrogen SulfideIsothiocyanatesKATP ChannelsLarge-Conductance Calcium-Activated Potassium ChannelssulforaphaneSulfoxidesVasodilator AgentsCerebral circulationcranial windowgaseous mediatorshydrogen sulfideisothiocyanatenewborn pigspotassium channels

Identifiers

PMID31594422
PMCPMC7786849
OpenAlexW2979929296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.