Evidence map›Paper›PMID 31594392›Full record

ArticleCirculation. Arrhythmia and electrophysiology2019

Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation.

Rafael J Ramirez, Yoshio Takemoto, Raphaël P Martins, David Filgueiras-Rama, Steven R Ennis, Sergey Mironov, Sandesh Bhushal, Makarand Deo, Sridharan Rajamani, Omer Berenfeld and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Ranolazine depresses conduction of rapid atrial depolarizations in a beating rabbit heart model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Rafael J RamirezCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Yoshio TakemotoCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Raphaël P MartinsCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
David Filgueiras-RamaCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Steven R EnnisCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Sergey MironovCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Sandesh BhushalDepartment of Engineering, Norfolk State University, VA (S.B., M.D.).
Makarand DeoDepartment of Engineering, Norfolk State University, VA (S.B., M.D.).
Sridharan RajamaniGilead Sciences, Foster City, CA (S.R., L.B.).
Omer BerenfeldCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Luiz BelardinelliGilead Sciences, Foster City, CA (S.R., L.B.).
José JalifeCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
Sandeep V PanditCenter for Arrhythmia Research, Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor (R.J.R., Y.T., R.P.M., D.F.-R., S.R.E., S.M., O.B., J.J., S.V.P.).
RCA (United States) · USNorfolk State University · USAmgen (United States) · USGilead Sciences (United States) · US

Funding

Intermolecular Interactions of NaV1.5 and Kir2.1 In Ion Channel DiseasesR01HL122352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2015 to 2018
$1.9M
Mapping Electrical Activation in Atrial FibrillationR01HL118304 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL118304NHLBI NIH HHS R01 HL122352
6 · The paper itself

Abstract

backgroundRanolazine inhibits Na

methodsPxAF was maintained during acute stretch (N=8), and PsAF was induced by long-term atrial tachypacing (N=9). Isolated, Langendorff-perfused sheep hearts were optically mapped.

resultsIn PxAF ranolazine (10 μmol/L) reduced dominant frequency from 8.3±0.4 to 6.2±0.5 Hz (

conclusionsPxAF and PsAF respond differently to ranolazine. Cardioversion in the former can be attributed partly to decreased dominant frequency and singularity point density, and prolongation of AFCL. In the latter, increased dispersion of AFCL and likely vortex shedding contributes to rotor formation, compensating for any rotor loss, and may underlie the inefficacy of ranolazine to terminate PsAF.

Indexed as

AnimalsAtrial FibrillationBody Surface Potential MappingDisease Models, AnimalHeart Conduction SystemHeart RateMaleRanolazineSheepSodium Channel BlockersRanolazineSodium Channel Blockersantiarrhythmic drugsatrial fibrillationcatheter ablationdofetilidedominant frequencyranolazinerotors

Identifiers

PMID31594392
PMCPMC6788778
OpenAlexW2980197986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.