Evidence map›Paper›PMID 31594247›Full record

ArticleJournal of Parkinson's disease2020

The Transition from Standing to Walking Is Affected in People with Parkinson's Disease and Freezing of Gait.

Sommer L Amundsen Huffmaster, Chiahao Lu, Paul J Tuite, Colum D MacKinnon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Association of sleep disturbance and freezing of gait in Parkinson disease: prevention/delay implications.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sommer L Amundsen HuffmasterDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Chiahao LuDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Paul J TuiteDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHNSON, MATTHEW DOUGLAS · 2016 to 2020
$9.1M
Pathway targeted deep brain stimulation for Parkinson's diseaseR01NS085188 · NINDS · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM, MCINTYRE, CAMERON · 2013 to 2017
$3.4M
Predictors of progression to freezing of gait in Parkinson's diseaseR01NS088679 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2015 to 2018
$1.6M
Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's diseaseR01NS070264 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2011 to 2013
$866k
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494NINDS NIH HHS P50 NS098573NINDS NIH HHS R01 NS070264NINDS NIH HHS R01 NS085188NINDS NIH HHS R01 NS088679
6 · The paper itself

Abstract

backgroundIt has been hypothesized that freezing of gait (FOG) in people with Parkinson's disease (PD) is due to abnormal coupling between posture and gait.

objectiveIn this study, we examined the relationship between anticipatory postural adjustments (APAs) preceding gait initiation and the kinematics of the first two steps between people with FOG and without FOG.

methodsThe kinetics and kinematics of self-initiated gait were recorded in 25 people with PD (11 with FOG, 14 without FOG). Outcome variables included the amplitude and timing of the ground reaction forces (GRFs), center of pressure (CoP) shifts and the spatial and temporal characteristics of the first and second steps.

resultsThe magnitude and timing of the APA phase of gait initiation were not significantly different between participants with and without FOG, yet the first step in the FOG group was distinguished by a significantly wider and less variable first step width, followed by a subsequent wider and shortened second step with reduced toe clearance. Multiple linear regression showed that the relationship between the initial conditions (stance width), APAs (posterior shift of the CoP) and the kinematics of the first step were different between groups with a significantly increased slope in the FOG group.

conclusionThese findings demonstrate that the transition from standing to walking is different between those with and without FOG and that alterations in the initial conditions or APAs are more likely to impact the execution of the two steps in people with FOG.

Indexed as

Standing PositionAgedBiomechanical PhenomenaFemaleGait Disorders, NeurologicHumansMaleMiddle AgedParkinson DiseasePostural BalanceWalkinganticipatory postural adjustmentsGait initiationParkinson’s diseasestepping

Identifiers

PMID31594247
PMCPMC7069602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.