ArticleBehavioural brain research2020
Effects of monoamine depletion on the ketamine-induced locomotor activity of preweanling, adolescent, and adult rats: Sex and age differences.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway.Zoological research · 2022Article
- "K-Powder" Exposure during Adolescence Elicits Psychiatric Disturbances Associated with Oxidative Stress in Female Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring.Biology of sex differences · 2022Article
- Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague-Dawley rats.Journal of neuroinflammation · 2022Article
- Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression.Psychopharmacology · 2022Article
- (R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency.Translational psychiatry · 2021Article
- Importance of dopaminergic neurotransmission for the RU 24969-induced locomotor activity of male and female rats during the preweanling period.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Use and abuse of dissociative and psychedelic drugs in adolescence.Pharmacology, biochemistry, and behavior · 2021Review
- Ketamine beyond anesthesia: Antidepressant effects and abuse potential.Behavioural brain research · 2020Article
- MK801-induced locomotor activity in preweanling and adolescent male and female rats: role of the dopamine and serotonin systems.Psychopharmacology · 2020Article
- Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects.Neurotoxicity research · 2020Article
- Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences.Behavioural brain research · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Ketamine significantly increases the locomotor activity of rodents, however this effect varies according to the sex and age of the animal being tested. To determine the role monoamine systems play in ketamine's locomotor activating effects: (a) male and female preweanling, adolescent, and adult rats were pretreated with vehicle or the monoamine depleting agent reserpine (1 or 5 mg/kg), and (b) the behavioral actions of ketamine (20 or 40 mg/kg) were then compared to d-amphetamine (2 mg/kg) and cocaine (10 or 15 mg/kg). The ability of reserpine to deplete dorsal striatal dopamine (DA) and serotonin (5-HT) in male and female rats was determined using HPLC. Ketamine caused substantial increases in the locomotion of preweanling rats and older female rats (adolescents and adults), but had only small stimulatory effects on adolescent and adult male rats. When compared to cocaine and d-amphetamine, ketamine was especially sensitive to the locomotor-inhibiting effects of monoamine depletion. Ketamine-induced locomotion is at least partially mediated by monoamine systems, since depleting DA and 5-HT levels by 87-96% significantly attenuated the locomotor activating effects of ketamine in male and female rats from all three age groups. When administered to reserpine-pretreated rats, ketamine produced a different pattern of behavioral effects than either psychostimulant, suggesting that ketamine does not stimulate locomotor activity via actions at the presynaptic terminal. Instead, our results are consistent with the hypothesis that ketamine increases locomotor activity through a down-stream mechanism, possibly involving ascending DA and/or 5-HT projection neurons.
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