ReviewJournal of the American Chemical Society2019
Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.
Review in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 263 citations in OpenAlex.
- Composition-tunable polycarboxylic acid-stabilized ultrasmall amorphous paramagnetic nanoclusters as multifunctional MRI contrast agents.Materials today. Bio · 2026Article
- Design Strategies for Developing Chiral Macrocyclic Chelators as a Diagnostic Tool.Accounts of chemical research · 2026Article
- Nuclear Spin Relaxation Modulation of Fluorinated Deep Eutectic Solvents for Radiofrequency Information Encoding and Display.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- AND-logic MRI contrast by water flux modulation.Chemical science · 2026Article
- Inner- and Second-Sphere Interactions of Co(II) and Fe(II) Parashift Agents with Lactate, Trifluorolactate, and Fluoride.Inorganic chemistry · 2026Article
- Isomerism and Relaxation Properties of Lanthanide(III) Complexes of a Ditopic Ligand with Two DO3A Units Bridged by a Methylene-bis(phosphinate) Spacer.Inorganic chemistry · 2026Article
- Investigating Cu(II) Complexes for MRI: A Comprehensive Approach Using EPR, Relaxometry, and Computational Modeling.Inorganic chemistry · 2026Article
- Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Convergent Evolution: Self-Assembly of Small Molecule, Polymeric, and Inorganic Contrast Agents toward Advanced MRI.Journal of the American Chemical Society · 2025Review
- Superhydrophilic FeAngewandte Chemie (International ed. in English) · 2025Article
- A molecular probe for detecting cholinesterase activity in MRI.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Monitoring Pharmacological Treatment of Breast Cancer with MRI.Current issues in molecular biology · 2025Review
- Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging.Advanced healthcare materials · 2025Review
- Recent Advances in the Development of Metal-Glycoconjugates for Medicinal Applications.Molecules (Basel, Switzerland) · 2025Review
- Gadolinium-Conjugated Lipoic Acid Hydrogels for Magnetic Resonance Imaging.ACS applied bio materials · 2025Article
- Sinapic Acid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents That Target Transforming Growth Factor β‑Activated Kinase 1 (TAK1).ACS pharmacology & translational science · 2025Article
- A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy.Materials today. Bio · 2025Article
- Binuclear Lanthanide Complexes as Magnetic Resonance and Optical Imaging Probes for Redox Sensing.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Magnetic-susceptibility-dependent ratiometric probes for enhancing quantitative MRI.Nature biomedical engineering · 2025Article
- Chiral Switch of Gadopiclenol: New Standards in MRI Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular levels. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and functional information. However, it has limited applications in the field of molecular imaging due to its low sensitivity. To expand the capability of MRI to encompass molecular imaging applications, we introduced bioresponsive Gd(III)-based magnetic resonance contrast agents (GBCAs) in 1997. Since that time, many research groups across the globe have developed new examples of bioresponsive GBCAs. These contrast agents have shown great promise for visualizing several biochemical processes, such as gene expression, neuronal signaling, and hormone secretion. They are designed to be conditionally retained, or activated,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.