Evidence map›Paper›PMID 31593600›Full record

ArticleThe Journal of infectious diseases2019

Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests.

Ruvandhi R Nathavitharana, Christina Yoon, Peter Macpherson, David W Dowdy, Adithya Cattamanchi, Akos Somoskovi, Tobias Broger, Tom H M Ottenhoff, Nimalan Arinaminpathy, Knut Lonnroth and 5 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Evaluation of C-Reactive Protein and Computer-Aided Analysis of Chest X-rays as Tuberculosis Triage Tests at Health Facilities in Lesotho and South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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  15. The Quest for a Child-Friendly Tuberculosis Triage Test.Journal of the Pediatric Infectious Diseases Society · 2022
    Article
  16. Diagnostic Accuracy of the Cepheid 3-gene Host Response Fingerstick Blood Test in a Prospective, Multi-site Study: Interim Results.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  17. Article
  18. Asia emerges as a hotbed of diagnostic innovations for tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2021
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  19. Article
  20. Evaluation of Triage Tests When Existing Test Capacity Is Constrained: Application to Rapid Diagnostic Testing in COVID-19.Medical decision making : an international journal of the Society for Medical Decision Making · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruvandhi R NathavitharanaDepartment of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston.
Christina YoonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco.
Peter MacphersonDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom.
David W DowdyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Adithya CattamanchiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco.
Akos SomoskoviIntellectual Ventures Laboratory, Global Good Fund, Bellevue, Washington.
Tobias BrogerFoundation for Innovative Diagnostics (FIND), Geneva, Switzerland.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, The Netherlands.
Nimalan ArinaminpathyMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Stockholm, Sweden.
Knut LonnrothDepartment of Public Health Sciences, Karolinska Instituet, Stockholm, Sweden.
Klaus ReitherUniversity of Basel, Switzerland.
Frank CobelensDepartment of Global Health, Amsterdam UMC, University of Amsterdam, The Netherlands.
Christopher GilpinWorld Health Organization, Geneva, Switzerland.
Claudia M DenkingerFoundation for Innovative Diagnostics (FIND), Geneva, Switzerland.
Samuel G SchumacherUniversity Hospital Heidelberg, Division of Tropical Medicine, Centre of Infectious Diseases, Germany.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Optimizing Diagnostic Strategies for TB Transmission Control in Health-Care FacilitiesK23AI132648 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NATHAVITHARANA, RUVANDHI · 2018 to 2022
$945k
Evaluation of novel tuberculosis screening strategies for people living with HIVK23AI114363 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOON, CHRISTINA · 2014 to 2018
$943k
Medical Research Council MR/R015600/1NIAID NIH HHS K23 AI114363NIAID NIH HHS K23 AI132648NIAID NIH HHS P30 AI060354Wellcome Trust 206575Wellcome Trust 206575/Z/17/ZWorld Health Organization 001
6 · The paper itself

Abstract

Approximately 3.6 million cases of active tuberculosis (TB) go potentially undiagnosed annually, partly due to limited access to confirmatory diagnostic tests, such as molecular assays or mycobacterial culture, in community and primary healthcare settings. This article provides guidance for TB triage test evaluations. A TB triage test is designed for use in people with TB symptoms and/or significant risk factors for TB. Triage tests are simple and low-cost tests aiming to improve ease of access and implementation (compared with confirmatory tests) and decrease the proportion of patients requiring more expensive confirmatory testing. Evaluation of triage tests should occur in settings of intended use, such as community and primary healthcare centers. Important considerations for triage test evaluation include study design, population, sample type, test throughput, use of thresholds, reference standard (ideally culture), and specimen flow. The impact of a triage test will depend heavily on issues beyond accuracy, primarily centered on implementation.

Indexed as

Practice Guidelines as TopicAdultBiological AssayBiomarkersBlood CultureChildCohort StudiesCross-Sectional StudiesDiagnostic Tests, RoutineHumansMycobacterium tuberculosisReference StandardsResearch DesignRisk FactorsSensitivity and SpecificitySputumBiomarkersdiagnosticsstudy design guidancetarget product profilestriagetuberculosis

Identifiers

PMID31593600
PMCPMC6782021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.