Evidence map›Paper›PMID 31593581›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Sarcopenia Characteristics Are Associated with Incident Mobility Limitations in African Caribbean Men: The Tobago Longitudinal Study of Aging.

Adam J Santanasto, Iva Miljkovic, Ryan K Cvejkus, Victor W Wheeler, Joseph M Zmuda

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Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Adam J SantanastoDepartment of Epidemiology, University of Pittsburgh, Pennsylvania.
Iva MiljkovicDepartment of Epidemiology, University of Pittsburgh, Pennsylvania.
Ryan K CvejkusDepartment of Epidemiology, University of Pittsburgh, Pennsylvania.
Victor W WheelerTobago Health Studies Office, Scarborough, Trinidad & Tobago.
Joseph M ZmudaDepartment of Epidemiology, University of Pittsburgh, Pennsylvania.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
Ectopic adiposity in black men with high type 2 diabetes riskR01DK097084 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2013 to 2016
$1.9M
Training in Molecular Epidemiology: Linking Genes to Physical Function in Older AdultsK01AG057726 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANTANASTO, ADAM J · 2018 to 2022
$582k
NIA NIH HHS K01 AG057726NIA NIH HHS P30 AG024827NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK097084
6 · The paper itself

Abstract

backgroundSarcopenia varies by ethnicity, and has a major impact on health in older adults. However, little is known about sarcopenia characteristics in African ancestry populations outside the United States. We examined sarcopenia characteristics in 2,142 African Caribbean men aged 59.0 ± 10.4 years (range: 40-92 years) in Tobago, and their association with incident mobility limitations in those aged 55+ (n = 738).

methodsBody mass index (BMI), grip strength, dual-x-ray absorptiometry (DXA) appendicular lean mass (ALM), and self-reported mobility limitations were measured at baseline, and 6 years later. Change in sarcopenia characteristics, including grip strength, grip strength/BMI, ALMBMI, and ALM/ht2, were determined. Foundations for the National Institutes of Health Sarcopenia Project (FNIH) and European Working Group for Sarcopenia in Older People 2 (EWGSOP2) cut-points were also examined. Odds ratios (OR) and 95% confidence intervals (CI) for mobility limitation were calculated using multivariable linear regression models adjusted for covariates.

resultsOverall, sarcopenia prevalence was quite low using the FNIH (0.3%) and EWGSOP2 (0.6%) operational cut-points, but was higher in those aged 75+ (2.1% [FNIH] and 3.7% [EWGSOP2]). Prevalence was also higher when based on "weakness", versus "low ALM." When sarcopenia markers were examined separately, baseline levels, but not changes, were associated with incident mobility limitations. Baseline grip strength/BMI was a particularly strong risk factor for incident mobility limitations (OR per SD: 0.50; 95% CI: 0.37-0.68).

conclusionsOur findings suggest that grip strength normalized to body mass, measured at one time point, may be a particularly useful phenotype for identifying African Caribbean men at risk for future mobility limitations.

Indexed as

Mobility LimitationAdultAgedAged, 80 and overAge FactorsBlack PeopleBody Mass IndexHand StrengthHumansIncidenceLongitudinal StudiesMaleMiddle AgedRisk AssessmentSarcopeniaTrinidad and TobagoMinority agingMusclePhysical functionSarcopenia

Identifiers

PMID31593581
PMCPMC7302169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.