ArticleAlcoholism, clinical and experimental research2019
Spatial Navigation in Children and Young Adults with Fetal Alcohol Spectrum Disorders.
Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Developmental exposure to legacy environmental contaminants, medial temporal lobe volumes and spatial navigation memory in late adolescents.Environmental research · 2025Article
- The Neurobiology of Learning and Memory in Rodent Models of Fetal Alcohol Spectrum Disorders.Advances in experimental medicine and biology · 2025Review
- Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children.Alcohol, clinical & experimental research · 2024Article
- Sex-specific Differences in Resting Oscillatory Dynamics in Children with Prenatal Alcohol Exposure.Neuroscience · 2024Article
- Impact of low-level prenatal alcohol exposure and maternal stress on autonomic regulation.Pediatric research · 2024Article
- Unraveling the complex relationship between prenatal alcohol exposure, hippocampal LTP, and learning and memory.Frontiers in molecular neuroscience · 2023Review
- Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory.Frontiers in neuroscience · 2023Article
- Magnitude comparison and automaticity in number processing in adolescents with prenatal alcohol exposure: An event-related potentials study.Alcoholism, clinical and experimental research · 2022Article
- Associations between developmental exposure to environmental contaminants and spatial navigation in late adolescence.New directions for child and adolescent development · 2022Article
- Altered Resting-State Neural Oscillations and Spectral Power in Children with Fetal Alcohol Spectrum Disorder.Alcoholism, clinical and experimental research · 2021Article
- Reduced Hippocampal Volumes Partially Mediate Effects of Prenatal Alcohol Exposure on Spatial Navigation on a Virtual Water Maze Task in Children.Alcoholism, clinical and experimental research · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRodent studies have consistently shown that prenatal alcohol exposure (PAE) impairs performance on the Morris water maze (MWM), a test of spatial navigation. A previous study comparing boys with fetal alcohol syndrome (FAS) to controls found poorer performance on the virtual water maze (VWM), a human analogue of the MWM. We examined PAE effects on virtual navigation in both sexes using the VWM in a moderately exposed Detroit cohort (N = 104; mean = 19.4 year) and a heavily exposed Cape Town, South African cohort (N = 62; mean = 10.4 year).
methodsThe task requires the participant to learn the location of a hidden platform in a virtual pool of water. The set of acquisition trials requires the participant to learn the location of the hidden platform and to return to that location repeatedly. The single-probe trial requires the participant to return to that location without knowing that the platform has been removed.
resultsNo effects of FASD diagnostic group or PAE were detected on virtual navigation in the Detroit moderately exposed cohort. By contrast, in the more heavily exposed Cape Town cohort, the FAS/partial FAS (PFAS) group took longer to locate the hidden platform during acquisition than nonsyndromal heavily exposed (HE) and control groups, an effect that persisted even after controlling for IQ. Among boys, both the FAS/PFAS and HE groups performed more poorly than controls during acquisition, and both boys and girls born to women who binge drank performed more poorly than those born to abstainers/light drinkers. Both amount and frequency of PAE were related to poorer performance during the probe trial at 10 years of age.
conclusionsThese data demonstrate deficits in spatial navigation among heavily exposed syndromal boys and girls and in nonsyndromal exposed boys.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.