Evidence map›Paper›PMID 31593110›Full record

ArticleMedicine2019

Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease.

Ruilai Jiang, Chunjiao Rong, Ronghu Ke, Shuiyan Meng, Xiumei Yan, Honglin Ke, Shaochang Wu

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  5. p.N370SInternational journal of molecular sciences · 2025
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  10. [Recent advances on the role of exosomes in neurodegenerative diseases].Se pu = Chinese journal of chromatography · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ruilai JiangDepartment of Emergency, the Second People's Hospital of Lishui, Lishui, Zhejiang Province.
Chunjiao RongDepartment of Emergency, the Second People's Hospital of Lishui, Lishui, Zhejiang Province.
Ronghu KeDepartment of Plastic and Reconstructive Surgery.
Shuiyan MengDepartment of Emergency, the Second People's Hospital of Lishui, Lishui, Zhejiang Province.
Xiumei YanDepartment of Emergency, the Second People's Hospital of Lishui, Lishui, Zhejiang Province.
Honglin KeDepartment of Emergency, Huashan Hospital, Fudan University School of Medicine, Shanghai, China.
Shaochang WuDepartment of Emergency, the Second People's Hospital of Lishui, Lishui, Zhejiang Province.
Xian Yang Central Hospital · CNLishui City People's Hospital · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanometer-sized vesicles with intercellular communication functions, and their encapsulated proteins may participate in the pathological process of neurodegenerative disorders. The aim of this study was to identify the protein changes of serum exosomes in Parkinson disease (PD) patients with different disease progress types, and to identify potential biomarkers. The exosomes of PD patients with different severity and healthy control group were isolated from serum. The exosome proteins were analyzed by mass spectrometry with label-free quantitative proteomics. A total of 429 proteins were identified, of which 14 were significantly different in mild and severe PD patients. The expression levels of 7 proteins, including pigmented epithelium-derived factor, afamin, apolipoprotein D and J, were significantly increased in PD patients. The expression levels of 7 proteins, including complement C1q and protein Immunoglobulin Lambda Variable 1-33 (IGLV1-33)Cluster -33, were decreased in PD patients. These differentially expressed proteins were analyzed by gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis, which confirmed that the interaction between prion diseases and ECM receptors was the most significant pathways of enrichment. The changes of proteins and pathways may be related to the pathophysiological mechanism of PD. Therefore, some of these proteins could be considered as potential biomarkers for early PD diagnosis.

Indexed as

AgedAged, 80 and overBiomarkersDisease ProgressionExosomesFemaleGene OntologyHumansMaleParkinson DiseaseProteomicsSeverity of Illness IndexBiomarkers

Identifiers

PMID31593110
PMCPMC6799836
OpenAlexW2979767394

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.