Evidence map›Paper›PMID 31592938›Full record

ArticlePsychosomatic medicine

The Longitudinal Association of Reduced Vagal Tone With Burnout.

Magdalena K Wekenborg, LaBarron K Hill, Julian F Thayer, Marlene Penz, Ralf Arne Wittling, Clemens Kirschbaum

Abstract read
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Biological Markers of Burnout Severity: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026
    Pooled it
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  7. Association Between Phasic Vagal-Mediated Heart Rate Variability and Momentary Exhaustion in Daily Life.Stress and health : journal of the International Society for the Investigation of Stress · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena K WekenborgFrom the Department of Psychology (Wekenborg, Penz, Kirschbaum), TU Dresden, Dreseden, Germany; Department of Psychiatry and Behavioral Sciences (Hill) and Center for the Study of Aging and Human Development (Hill), Duke University Medical Center, Durham, North Carolina; Department of Psychology (Thayer), The Ohio State University, Columbus, Ohio; and ZNF - Center for Neuroscience Research NPO (Wittling), Trier, Germany.
LaBarron K Hill
Julian F Thayer
Marlene Penz
Ralf Arne Wittling
Clemens Kirschbaum

Funding

Depression and Heart Failure Disease ProgressionR01HL121708 · NHLBI · DUKE UNIVERSITY · PI SHERWOOD, ANDREW · 2014 to 2018
$4.2M
NHLBI NIH HHS R01 HL121708NIMHD NIH HHS L60 MD009947
6 · The paper itself

Abstract

objectivePrevious research indicates a link between burnout symptoms and reduced vagally mediated heart rate variability (HRV); however, the directionality of this relationship is still largely unknown. The objective of the present study was to examine the longitudinal relationship between HRV and burnout symptoms for 1 year, with a special focus on the emotional exhaustion (EE) burnout subdimension, which remains inadequately distinguished from overlapping with depressive symptoms.

methodsHere we present HRV and behavioral data from 167 individuals (mean [SD] age = 43.43 [11.78] years; 30.5% male) who attended two biomarker samplings (T1 and T2) of the Dresden Burnout Study approximately 12 months apart.

resultsIn hierarchical linear regression analyses, T1 HRV significantly inversely predicted T2 overall burnout symptoms (β = -.16; p = .03) and EE (β = -.23; p = .02), adjusting for age, sex, body mass index, adverse health behaviors, and depressive symptoms. Importantly, only high EE at T1 (β = -.22; p = .04), and not the T1 Maslach Burnout Inventor total score, predicted reductions in HRV from T1 to T2.

conclusionsWe report for the first time longitudinal evidence that HRV is associated with changes in burnout symptoms, independently of depressive symptoms. Results suggest vagal dysfunction being predictive and specific for burnout symptoms, making HRV a promising starting point for the explanation of biophysiological mechanisms underlying burnout symptoms and cardiovascular diseases. The finding of only EE at T1 being predictive for changes in HRV underscores the importance of exhaustion for modulations in autonomic regulation.

Indexed as

AdultAgedAutonomic Nervous SystemBurnout, PsychologicalDepressionFemaleHeart RateHumansLongitudinal StudiesMaleMiddle AgedVagus NerveYoung Adult

Identifiers

PMID31592938
PMCPMC6832856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.