Evidence map›Paper›PMID 31592655›Full record

ArticleJournal of the American Chemical Society2019

Sub-20 nm Core-Shell-Shell Nanoparticles for Bright Upconversion and Enhanced Förster Resonant Energy Transfer.

Chris Siefe, Randy D Mehlenbacher, Chunte Sam Peng, Yunxiang Zhang, Stefan Fischer, Alice Lay, Claire A McLellan, A Paul Alivisatos, Steven Chu, Jennifer A Dionne

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Enhanced Single-Particle Upconversion Imaging via Energy Migration Boosting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  8. Article
  9. Inhibiting concentration quenching in YbNature communications · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chris SiefeDepartment of Materials Science and Engineering , Stanford University , Stanford , California 94305 , United States.ORCID 0000-0002-8554-081X
Randy D MehlenbacherDepartment of Materials Science and Engineering , Stanford University , Stanford , California 94305 , United States.
Chunte Sam PengDepartment of Physics , Stanford University , Stanford , California 94305 , United States.
Yunxiang ZhangDepartment of Physics , Stanford University , Stanford , California 94305 , United States.
Stefan FischerDepartment of Materials Science and Engineering , Stanford University , Stanford , California 94305 , United States.
Alice LayDepartment of Applied Physics , Stanford University , Stanford , California 94305 , United States.
Claire A McLellanDepartment of Materials Science and Engineering , Stanford University , Stanford , California 94305 , United States.
A Paul AlivisatosDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.ORCID 0000-0001-6895-9048
Steven ChuDepartment of Physics , Stanford University , Stanford , California 94305 , United States.
Jennifer A DionneDepartment of Materials Science and Engineering , Stanford University , Stanford , California 94305 , United States.

Funding

The biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4M
Noninvasive deep-tissue single-cell imaging and nanoprobe developmentR01GM128089 · NIGMS · STANFORD UNIVERSITY · PI CHU, STEVEN, RAO, JIANGHONG · 2018 to 2021
$2.2M
Cancer-Translational Nanotechnology Training Program (Cancer-TNT)T32CA196585 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W, RAO, JIANGHONG · 2015 to 2019
$1.8M
Developing nanoparticle optical reporters of compressive, tensile, and shear forces for use in living cells and tissues.R21GM129879 · NIGMS · STANFORD UNIVERSITY · PI DIONNE, JENNIFER A., GOODMAN, MIRIAM B · 2018 to 2019
$432k
NCI NIH HHS T32 CA196585NIGMS NIH HHS R01 GM128089NIGMS NIH HHS R21 GM129879NINDS NIH HHS R35 NS105092
6 · The paper itself

Abstract

Upconverting nanoparticles provide valuable benefits as optical probes for bioimaging and Förster resonant energy transfer (FRET) due to their high signal-to-noise ratio, photostability, and biocompatibility; yet, making nanoparticles small yields a significant decay in brightness due to increased surface quenching. Approaches to improve the brightness of UCNPs exist but often require increased nanoparticle size. Here we present a unique core-shell-shell nanoparticle architecture for small (sub-20 nm), bright upconversion with several key features: (1) maximal sensitizer concentration in the core for high near-infrared absorption, (2) efficient energy transfer between core and interior shell for strong emission, and (3) emitter localization near the nanoparticle surface for efficient FRET. This architecture consists of β-NaYbF

Indexed as

Fluorescence Resonance Energy TransferParticle SizeNanoparticlesOptical Phenomena

Identifiers

PMID31592655
PMCPMC8259630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.