Evidence map›Paper›PMID 31592538›Full record

ArticleJournal of surgical oncology2019

Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix.

Adam C Fields, Pamela Lu, Andrea Enzinger, Joel Goldberg, Jennifer Irani, Ronald Bleday, Garrett Nash, Nelya Melnitchouk

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Goblet cell carcinoid of the appendix: Six case reports.World journal of clinical cases · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. New insights in the pathology of peritoneal surface malignancy.Journal of gastrointestinal oncology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam C FieldsDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID http://orcid.org/0000-0001-9029-7044
Pamela LuDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID http://orcid.org/0000-0003-4960-3753
Andrea EnzingerCenter for Gastrointestinal Oncology, Dana Farber Cancer Center, Boston, Massachusetts.
Joel GoldbergDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Jennifer IraniDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Ronald BledayDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Garrett NashDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID http://orcid.org/0000-0001-9833-2625
Nelya MelnitchoukDivision of Colorectal Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Video Informed Consent Tools to Improve Care for Patients With Advanced Pancreatic CancerK07CA204201 · NCI · DANA-FARBER CANCER INST · PI ENZINGER, ANDREA C · 2016 to 2020
$878k
MSK core grant P30CA008748NCI NIH HHS K07 CA204201NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundGoblet cell carcinoid (GCC) tumors of the appendix are a rare malignancy. We aim to examine the overall survival per stage and the relationship between different treatment modalities and outcomes for patients with GCC tumors of the appendix.

methodsWe identified patients with GCC tumors of the appendix from the National Cancer Database. The main outcome was overall patient survival and cox proportional hazard models were used to ascertain predictors of survival.

resultsThere were 2552 patients identified. The median age of diagnosis was 57 (interquartile range: 49-65) and 52.3% of patients were female. The 5-year survival for Stage I disease was 91.1% (95% confidence interval [CI]: 82.2%-95.7%), for Stage II disease was 90.5% (95% CI: 85.8%-93.7%), for Stage III disease was 57.0% (95% CI: 45.0%-67.3%), and for Stage IV disease was 18.9% (95% CI: 9.3%-31.0%). In a Cox proportional hazard model, older age (hazard ratio [HR]: 1.1; 95% CI: 1.03-1.12; P < .001), lymph node metastasis (HR: 6.9; 95% CI: 2.76-17.01; P < .001), and positive surgical margins (HR: 2.9; 95% CI:1.13-7.26; P = .003) were associated with worse overall survival for Stages I to III disease while only older age (HR: 1.03; 95% CI: 1.002-1.06; P = .04) was associated with worse overall survival for Stage IV disease.

conclusionsPatients with GCC tumors of the appendix who have the nonmetastatic disease have a high 5-year survival. We have identified several prognostic factors for GCC.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsAppendectomyAppendiceal NeoplasmsCarcinoid TumorCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisProspective StudiesSurvival Rateappendix tumorgoblet cell carcinoidoverall survival

Identifiers

PMID31592538
PMCPMC7428861

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.