ArticleJournal of the American Medical Informatics Association : JAMIA2020
Leaf: an open-source, model-agnostic, data-driven web application for cohort discovery and translational biomedical research.
Article in Journal of the American Medical Informatics Association : JAMIA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.Journal of medical Internet research · 2022Pooled it
- Outcomes After Fast Neutron Therapy for Locally Advanced Base of Tongue Adenoid Cystic Carcinoma.International journal of particle therapy · 2026Article
- Evaluating the performance and acceptability of an artificial intelligence digital health exercise platform in females with and without axial spondyloarthritis: a phase I study.Advances in rheumatology (London, England) · 2026Article
- Transformer-based relation extraction and concept normalization using an annotated clinical trials corpus.Scientific data · 2026Article
- EC2Seq2Sql: Patient-trial matching with LLM agents.PloS one · 2026Article
- Open Source Web Application (HealthTest) for Emotional Health and Wellness Management in University Students: Development and Usability Study.Online journal of public health informatics · 2025Article
- Experience of Older Adults and Their Family Members in the Kidney Transplant Evaluation.JAMA internal medicine · 2025Article
- The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project.Journal of medical Internet research · 2024Article
- Mycophenolate Mofetil Appears Effective for the Treatment of Patients With Refractory Crohn's Disease.Crohn's & colitis 360 · 2024Article
- Towards cross-application model-agnostic federated cohort discovery.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Understanding enterprise data warehouses to support clinical and translational research: impact, sustainability, demand management, and accessibility.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Sociotechnical feasibility of natural language processing-driven tools in clinical trial eligibility prescreening for Alzheimer's disease and related dementias.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- An Interactive Information Visualization System for Temporal Queries in a Large-scale COVID-19 EHR Dataset (COVID-SPHERE): development and qualitative evaluation.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Article
- LeafAI: query generator for clinical cohort discovery rivaling a human programmer.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Feasibility, Engagement, and Usability of a Remote, Smartphone-Based Contingency Management Program as a Treatment Add-On for Patients Who Use Methamphetamine: Single-Arm Pilot Study.JMIR formative research · 2023Article
- A data-driven approach to optimizing clinical study eligibility criteria.Journal of biomedical informatics · 2023Article
- A Query Engine for Self-controlled Case Series, with an application to COVID-19 EHR data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023Article
- Combined assessment of Epstein-Barr virus viral capsid antigen and Epstein-Barr virus nuclear antigen-1 serology for post-transplant lymphoproliferative disorder risk stratification in adult solid organ transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveAcademic medical centers and health systems are increasingly challenged with supporting appropriate secondary use of clinical data. Enterprise data warehouses have emerged as central resources for these data, but often require an informatician to extract meaningful information, limiting direct access by end users. To overcome this challenge, we have developed Leaf, a lightweight self-service web application for querying clinical data from heterogeneous data models and sources. MATERIALS AND
methodsLeaf utilizes a flexible biomedical concept system to define hierarchical concepts and ontologies. Each Leaf concept contains both textual representations and SQL query building blocks, exposed by a simple drag-and-drop user interface. Leaf generates abstract syntax trees which are compiled into dynamic SQL queries.
resultsLeaf is a successful production-supported tool at the University of Washington, which hosts a central Leaf instance querying an enterprise data warehouse with over 300 active users. Through the support of UW Medicine (https://uwmedicine.org), the Institute of Translational Health Sciences (https://www.iths.org), and the National Center for Data to Health (https://ctsa.ncats.nih.gov/cd2h/), Leaf source code has been released into the public domain at https://github.com/uwrit/leaf. DISCUSSION: Leaf allows the querying of single or multiple clinical databases simultaneously, even those of different data models. This enables fast installation without costly extraction or duplication.
conclusionsLeaf differs from existing cohort discovery tools because it does not specify a required data model and is designed to seamlessly leverage existing user authentication systems and clinical databases in situ. We believe Leaf to be useful for health system analytics, clinical research data warehouses, precision medicine biobanks, and clinical studies involving large patient cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.