SynthesisBJS open2019
Meta-analysis of epidural analgesia in patients undergoing pancreatoduodenectomy.
Synthesis in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04920019 (Opioid Sparing Effect of Thoracic Epidural Analgesia for Open Upper Abdominal Surgery), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Opioid Sparing Effect of Thoracic Epidural Analgesia for Open Upper Abdominal Surgery: Prospective Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Multimodal analgesia with continuous nerve blocks versus intravenous patient-controlled analgesia for pancreatectomy: a retrospective cohort study.Perioperative medicine (London, England) · 2026Article
- Reply to Edward, R. Comment on "Fernandez Martin et al. Analgesia for Upper Abdominal Surgery, a Scoping Review of the Current Fascial Plane Block Techniques.Journal of clinical medicine · 2026Article
- Comparison of epidural anesthesia and intravenous self-control analgesia on postoperative recovery quality in duodenectomy.World journal of gastrointestinal surgery · 2026Article
- Article
- National trends in perioperative epidural analgesia use for surgical patients.Journal of clinical anesthesia · 2024Article
- Pain management after abdominal surgery: requiem for epidural analgesia?The British journal of surgery · 2024Article
- Postoperative analgesia for upper gastrointestinal surgery: a retrospective cohort analysis.Perioperative medicine (London, England) · 2023Article
- Analgesic Modalities in Patients Undergoing Open Pancreatoduodenectomy-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Accidental epidural catheter removal rates and strength required for disconnection: a retrospective cohort and laboratory study.BMC anesthesiology · 2022Article
- Sublingual Sufentanil versus Standard-of-Care (Patient-Controlled Analgesia with Epidural Ropivacaine/Sufentanil or Intravenous Morphine) for Postoperative Pain Following Pancreatoduodenectomy: A Randomized Trial.Journal of pain research · 2022Article
- Regional Catheters for Postoperative Pain Control: Review and Observational Data.Anesthesiology and pain medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The optimal analgesic technique after pancreatoduodenectomy remains under debate. This study aimed to see whether epidural analgesia (EA) has superior clinical outcomes compared with non-epidural alternatives (N-EA) in patients undergoing pancreatoduodenectomy. Methods: A systematic review with meta-analysis was performed according to PRISMA guidelines. On 28 August 2018, relevant literature databases were searched. Primary outcomes were pain scores. Secondary outcomes were treatment failure of initial analgesia, complications, duration of hospital stay and mortality. Results: Three RCTs and eight cohort studies (25 089 patients) were included. N-EA treatments studied were: intravenous morphine, continuous wound infiltration, bilateral paravertebral thoracic catheters and intrathecal morphine. Patients receiving EA had a marginally lower pain score on days 0-3 after surgery than those receiving intravenous morphine (mean difference (MD) -0·50, 95 per cent c.i. -0·80 to -0·21; Conclusion: EA provides marginally lower pain scores in the first postoperative days than intravenous morphine, and appears to be associated with fewer complications, shorter duration of hospital stay and less mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.