Evidence map›Paper›PMID 31592450›Full record

ArticleEndocrinology, diabetes & metabolism2019

Steviol glucuronide, a metabolite of steviol glycosides, potently stimulates insulin secretion from isolated mouse islets: Studies in vitro.

Wenqian Gu, Andreas Rebsdorf, Camilla Anker, Søren Gregersen, Kjeld Hermansen, Jan M C Geuns, Per Bendix Jeppesen

Open access · goldAbstract read
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Wenqian GuDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Andreas RebsdorfDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Camilla AnkerDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Søren GregersenSteno Diabetes Center Aarhus Aarhus University Hospital Aarhus N Denmark.
Kjeld HermansenDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.
Jan M C GeunsLaboratory of Functional Biology KU Leuven Leuven Belgium.
Per Bendix JeppesenDepartment of Clinical Medicine Aarhus University Aarhus N Denmark.ORCID https://orcid.org/0000-0001-8042-7554
Aarhus University · DKSteno Diabetes Centers · DKVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsSteviol glycosides are the sweet components extracted from medicinal plant MATERIALS AND

methodsInsulin secretion was measured after 60 minutes static incubation of isolated mouse islets with (a) 10

resultsSVG dose-dependently increased insulin secretion from mouse islets with 10

conclusionThis is the first report to demonstrate that SVG stimulates insulin secretion in a dose- and glucose-dependent manner from isolated mouse islets of Langerhans. SVG may be the main active metabolite after oral intake of steviol glycosides.

Indexed as

insulin secretionmouse pancreatic isletssteviol glucuronidesteviol glycosides

Identifiers

PMID31592450
PMCPMC6775443
OpenAlexW2971733480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.