Evidence map›Paper›PMID 31592449›Full record

ArticleEndocrinology, diabetes & metabolism2019

Co-occurrence of breast cancer and neuroendocrine tumours: New genetic insights beyond Multiple Endocrine Neoplasia syndromes.

Vincent Larouche, Amit Akirov, Emily Thain, Raymond H Kim, Shereen Ezzat

Open access · goldAbstract read
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Summary ofGenes · 2020
    Pooled it
  3. Article
  4. Genomic ascertainment ofmedRxiv : the preprint server for health sciences · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vincent LaroucheDivision of Endocrinology and Metabolism Department of Medicine University Health Network University of Toronto Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-9337-8162
Amit AkirovDivision of Endocrinology and Metabolism Department of Medicine University Health Network University of Toronto Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-9376-344X
Emily ThainFamilial Cancer Clinic Princess Margaret Cancer Centre University Health Network Toronto Ontario Canada.
Raymond H KimFred A Litwin Family Centre in Genetic Medicine University Health Network Toronto Ontario Canada.
Shereen EzzatDivision of Endocrinology and Metabolism Department of Medicine University Health Network University of Toronto Toronto Ontario Canada.
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAge-standardized incidence of female breast cancer is 145.1 per 100000/year and 5.86 per 100000/year for neuroendocrine tumours (NET) in Canada. Evidence is scarce about gene variants that may predispose patients to develop both neoplasms. The objective of this study was to identify germline gene variants associated with this combination of tumours. DESIGN AND PATIENTS: A retrospective chart review (2007-2018) in a tertiary NET referral centre was completed. A series of 9 female patients with concurrent breast cancer and NET is presented. All patients underwent a 37 gene hereditary cancer next-generation sequencing panel.

resultsMean age was 61.4 years (35-85) at breast cancer diagnosis and 63.4 years (51-89) at NET diagnosis. Four patients had a pancreatic, three had a small bowel and two had a lung NET. Two patients were known cases of

conclusionThe first cases of a

Indexed as

breast neoplasmcarcinoid tumourendocrinologymedical geneticsmedical oncologyMultiple Endocrine Neoplasiamutationneuroendocrine tumours

Identifiers

PMID31592449
PMCPMC6775469
OpenAlexW2973052771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.