Evidence map›Paper›PMID 31592442›Full record

ArticleACS biomaterials science & engineering2019

DNA-Templated Strontium-Doped Calcium Phosphate Nanoparticles for Gene Delivery in Bone Cells.

Razieh Khalifehzadeh, Hamed Arami

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Biological and Medical Applications of Calcium Phosphate Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  8. Article
  9. Article
  10. Biodegradable calcium phosphate nanoparticles for cancer therapy.Advances in colloid and interface science · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Razieh KhalifehzadehDepartment of Chemical Engineering, Stanford University, Shriram Center, 443 Via Ortega, Stanford, California 94305, United States.
Hamed AramiDepartment of Radiology, Stanford University School of Medicine, James H. Clark Center, 318 Campus Drive, E-153, Stanford, California 94305, United States.ORCID 0000-0002-6409-4435
Stanford University · US

Funding

STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Cancer-Translational Nanotechnology Training Program (Cancer-TNT)T32CA196585 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W, RAO, JIANGHONG · 2015 to 2019
$1.8M
Engineering antiviral innate immunity for safe and effective microbicidesR33AI088597 · NIAID · UNIVERSITY OF WASHINGTON · PI BANEYX, FRANCOIS C · 2012 to 2014
$1.1M
Engineering antiviral innate immunity for safe and effective microbicidesR21AI088597 · NIAID · UNIVERSITY OF WASHINGTON · PI SHEN, HONG · 2010 to 2011
$384k
NCI NIH HHS T32 CA009695NCI NIH HHS T32 CA196585NIAID NIH HHS R21 AI088597NIAID NIH HHS R33 AI088597
6 · The paper itself

Abstract

Calcium phosphates (CaPs), constituents of the inorganic phase of natural bone, are highly biocompatible and biodegradable. Strontium (Sr) regulates the formation and resorption of bone. Incorporation of Sr into CaPs may target genes of interest to bone cells while regulating their function. In this work, we developed a single-step synthesis method to prepare Sr-doped CaP nanoparticles (SrCaP-DNA NPs) by using DNA as a template for controlling the mineralization and the stability of the colloidal solution. The resulting nanoparticles were monodispersed with well-controlled size, morphology, and composition. By using this method, we were able to fabricate CaP NPs with varying contents of Sr

Indexed as

bone tissue engineeringcalcium phosphategene deliverynanomedicine

Identifiers

PMID31592442
PMCPMC6779169
OpenAlexW2947785815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.