Evidence map›Paper›PMID 31592417›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

Acoustofluidic Synthesis of Particulate Nanomaterials.

Po-Hsun Huang, Shuaiguo Zhao, Hunter Bachman, Nitesh Nama, Zhishang Li, Chuyi Chen, Shujie Yang, Mengxi Wu, Steven Peiran Zhang, Tony Jun Huang

Erratum issuedAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Po-Hsun HuangDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.ORCID https://orcid.org/0000-0001-9600-0141
Shuaiguo ZhaoDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Hunter BachmanDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Nitesh NamaDepartment of Engineering Science and Mechanics Pennsylvania State University University Park PA 16802 USA.
Zhishang LiDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Chuyi ChenDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Shujie YangDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Mengxi WuDepartment of Engineering Science and Mechanics Pennsylvania State University University Park PA 16802 USA.
Steven Peiran ZhangDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.
Tony Jun HuangDepartment of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USA.ORCID https://orcid.org/0000-0003-1205-3313

Funding

ExoSOUND: An Acoustofluidic Device for Exosome IsolationR44GM125439 · NIGMS · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2017 to 2018
$1.9M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
An Acoustofluidic Device for Point-of-Care Sputum Processing and AnalysisR44HL126441 · NHLBI · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2016 to 2017
$1.5M
Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platformR33CA223908 · NCI · NORTHEASTERN UNIVERSITY · PI EVENS, ANDREW M, HUANG, TONY JUN · 2018 to 2020
$1.2M
An integrated acoustofluidic droplet-sorting platform for classification of lymphocyte activity and functional phenotyping at single cell levelR01GM127714 · NIGMS · NORTHEASTERN UNIVERSITY · PI KONRY, TANIA TALI · 2018 to 2021
$1.2M
NCI NIH HHS R33 CA223908NHLBI NIH HHS R44 HL126441NIGMS NIH HHS R01 GM127714NIGMS NIH HHS R01 GM132603NIGMS NIH HHS R44 GM125439
6 · The paper itself

Abstract

Synthesis of nanoparticles and particulate nanomaterials with tailored properties is a central step toward many applications ranging from energy conversion and imaging/display to biosensing and nanomedicine. While existing microfluidics-based synthesis methods offer precise control over the synthesis process, most of them rely on passive, partial mixing of reagents, which limits their applicability and potentially, adversely alter the properties of synthesized products. Here, an acoustofluidic (i.e., the fusion of acoustic and microfluidics) synthesis platform is reported to synthesize nanoparticles and nanomaterials in a controllable, reproducible manner through acoustic-streaming-based active mixing of reagents. The acoustofluidic strategy allows for the dynamic control of the reaction conditions simply by adjusting the strength of the acoustic streaming. With this platform, the synthesis of versatile nanoparticles/nanomaterials is demonstrated including the synthesis of polymeric nanoparticles, chitosan nanoparticles, organic-inorganic hybrid nanomaterials, metal-organic framework biocomposites, and lipid-DNA complexes. The acoustofluidic synthesis platform, when incorporated with varying flow rates, compositions, or concentrations of reagents, will lend itself unprecedented flexibility in establishing various reaction conditions and thus enable the synthesis of versatile nanoparticles and nanomaterials with prescribed properties.

Indexed as

acoustic streamingacoustofluidicsnanomaterialsnanoparticlessynthesis

Identifiers

PMID31592417
PMCPMC6774021

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.