ArticlePlastic and reconstructive surgery. Global open2019
Treatment of Horizontal Neck Wrinkles with Hyaluronic Acid Filler: A Retrospective Case Series.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.Journal of cosmetic dermatology · 2025Trial
- Hyaluronic Acid Compound Filling Plus Mesotherapy vs Botulinum Toxin A for the Treatment of Horizontal Neck Lines: A Multicenter, Randomized, Evaluator-Blinded, Prospective Study in Chinese Subjects.Aesthetic surgery journal · 2022Trial
- Six-Month Changes in Periorbital and Perioral Wrinkles and Facial Skin Quality following Low-Cross-Linked Hyaluronic Acid.Dermatology and therapy · 2026Article
- Efficacy and Safety of Platelet-Rich Plasma and Hyaluronic Acid Combination Treatment for Neck Rejuvenation in Thailand: A Prospective Study.Dermatology and therapy · 2026Article
- Efficacy and Safety of Hyaluronic Acid Fillers for Horizontal Neck Lines: A Systematic Review and Meta-Analysis.Aesthetic surgery journal. Open forum · 2026Review
- Needle-free Subcision and Hyaluronic Acid Injection Using CureJet for Horizontal Neck Fold Reduction Assessed by Ultrasound and 3-dimensional Analysis.Plastic and reconstructive surgery. Global open · 2025Article
- Progress in Neck Rejuvenation Injection Therapy.Aesthetic plastic surgery · 2025Review
- Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections.Journal of cosmetic dermatology · 2025Review
- Treatment of horizontal neck wrinkles by Endolift laser: Biometric measurement.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Horizontal necklines correction with absorbable braided polydioxanone threads: Case series.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Review
- Clinical Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Combined with L-carnosine for Horizontal Neck Wrinkles Treatment.Aesthetic plastic surgery · 2021Article
- Pan-Asian Consensus on Calcium Hydroxyapatite for Skin Biostimulation, Contouring, and Combination Treatments.The Journal of clinical and aesthetic dermatology · 2021Review
- Development and Validation of IBSA Photographic Scale for the Assessment of Neck Laxity.Clinical, cosmetic and investigational dermatology · 2021Article
- Patient Satisfaction Using Hybrid Cooperative Complexes of Hyaluronic Acid for Neck Laxity: A Survey of Asian Populations.Plastic and aesthetic nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal neck wrinkles are a common aesthetic deficiency but limited treatment options exist and none have been studied with follow-ups of over 2 months.
methodsThis dual-center, retrospective case series (Apr 2016-Jan 2017) included adult patients receiving CPM-HA to treat horizontal neck wrinkles. Patients were followed up for 40 weeks. CPM-HA treatment efficacy was evaluated through the Horizontal Neck Wrinkle Severity Scale and Global Aesthetic Improvement Scale (GAIS). Adverse events (AEs) and pain on injection, as assessed on the visual analogue scale, were documented.
resultsSixty-four lateral neck halves from 32 women (23-61 years) were analyzed. Significant improvement in wrinkle intensity, as assessed by Horizontal Neck Wrinkle Severity Scale, was observed from the second week onwards (1.352 ± 0.682,
conclusionsSubdermal injection of CPM-HA is safe and effective for treating horizontal neck wrinkles. Sustained improvement of wrinkle intensity up to 36 weeks and minimal AEs with no Tyndall effect were observed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.