Evidence map›Paper›PMID 31592376›Full record

ArticlePlastic and reconstructive surgery. Global open2019

Skin Protein Profile after Major Weight Loss and Its Role in Body Contouring Surgery.

José Renato B Gallo, Larissa B Maschio-Signorini, Celso R B Cabral, Debora A P de Campos Zuccari, Maurício L Nogueira, Antônio R Bozola, Patricia M Cury, Alessandra Vidotto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

José Renato B GalloDepartment of Plastic Surgery, Medicine Postgraduate Program, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Larissa B Maschio-SignoriniDepartment of Molecular Biology, Molecular Investigation of Cancer Laboratory (LIMC), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Celso R B CabralDepartment of Statistics, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
Debora A P de Campos ZuccariDepartment of Molecular Biology, Faculdade de Medicina de São José do Rio Preto (FAMERP); São José do Rio Preto, São Paulo, Brazil.
Maurício L NogueiraDepartment of Dermatological, Infectious and Parasitic Diseases, Virology Laboratory, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Antônio R BozolaDepartment of Plastic Surgery, Plastic Surgery Department, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
Patricia M CuryDra. Patrícia Maluf Cury is not tied to any specific department. She is the coordinator of the medical course at FACERES. Faculdade de Medicina FACERES, São José do Rio Preto, São Paulo, Brazil.
Alessandra VidottoMultiuser Laboratory, Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto, São Paulo, Brazil.
Faculdade de Medicina de São José do Rio Preto · BRFaculdade Ceres · BRUniversidade Federal do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation during morbid obesity significantly alters cutaneous tissue. Large weight loss achieved after bariatric surgery minimizes or halts damage caused by metabolic syndrome, but further deteriorates the clinical condition of skin. Postbariatric skin flaccidity produces major difficulties to plastic surgery. In this study, we analyzed differences in protein composition of the skin between patients with morbid obesity and those after large weight loss and established correlations between differentially expressed proteins and clinical characteristics of postbariatric skin tissue, to improve body contouring surgery techniques.

methodsSkin fragments were removed from the abdomen of 32 patients, who were allocated into 3 groups: morbidly obese, large weight loss without surgery, and postbariatric surgery. Samples were subjected to proteomic analysis, and the protein profiles of the groups were compared. Six differentially expressed proteins of clinical interest were validated by immunohistochemistry and statistical analysis.

resultsComparative analyses confirmed differences in protein profile of the skin between morbidly obese and large weight loss groups. A persistent increase in inflammatory markers such as haptoglobin was observed in all groups and decrease in the expression of collagen XIV, which regulates the physical properties of cutaneous tissue, was observed in the postbariatric group.

conclusionsHigh expression of haptoglobin associated with the decrease of Collagen XIV, vinculin, and periplakin in the groups after major weight losses, mainly postbariatric, confirm that the inflammatory lesion remains active in the skin and causes changes in its structural organization, with serious repercussions on its clinical characteristics and physical properties.

Identifiers

PMID31592376
PMCPMC6756662
OpenAlexW2969872433

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.