ReviewAcute medicine & surgery2019
Complement and coagulation cascades in trauma.
Review in Acute medicine & surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Neutrophil-Dominant Inflammatory Responses and Inflammation-Coagulation Burden After Extremity Acute Compartment Syndrome: A Retrospective Multi-Cohort Study.Journal of inflammation research · 2026Article
- In vitro and in vivo hemocompatibility study of fish swim bladder-derived biomaterials for the application of chronic venous disease.Journal of materials science. Materials in medicine · 2025Article
- Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Transcriptomics and proteomics reveal associations between myometrium and intrauterine adhesions.BMC women's health · 2025Article
- Common antimicrobials disrupt early zebrafish development through immune-cardiac signaling.Environmental science and ecotechnology · 2025Article
- Effects of Different Processing on miRNA and Protein in Small Extracellular Vesicles of Goat Dairy Products.Nutrients · 2024Article
- Extending the post-thaw shelf-life of cryoprecipitate when stored at refrigerated temperatures.Vox sanguinis · 2024Article
- Genomic Insights and Conservation Priorities for Kongshan Cattle: A Whole-Genome Resequencing Approach.Animals : an open access journal from MDPI · 2024Article
- Review
- Impact of Immunopathy and Coagulopathy on Multi-Organ Failure and Mortality in a Lethal Porcine Model of Controlled and Uncontrolled Hemorrhage.International journal of molecular sciences · 2024Article
- [Research advances on the role of complement system activation in post-burn immunity].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Microbial evasion of the complement system: a continuous and evolving story.Frontiers in immunology · 2023Review
- Transcriptomic analysis of spleen B cell revealed the molecular basis of bursopentin on B cell differentiation.Veterinary research · 2022Article
- Intertwined pathways of complement activation command the pathogenesis of lupus nephritis.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Effects ofAnimals : an open access journal from MDPI · 2022Article
- Complement Activation in Patients With Heat-Related Illnesses: Soluble CD59 Is a Novel Biomarker Indicating Severity of Heat-Related Illnesses.Critical care explorations · 2022Article
- Traumatized triad of complementopathy, endotheliopathy, and coagulopathy - Impact on clinical outcomes in severe polytrauma patients.Frontiers in immunology · 2022Article
- Indices of complement activation and coagulation changes in trauma patients.Trauma surgery & acute care open · 2022Article
- Liver regeneration biology: Implications for liver tumour therapies.World journal of clinical oncology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trauma remains a major cause of death throughout the world, especially for patients younger than 45 years. Due to rapid advances in clinical management, both in the acute and prehospital settings, trauma patients survive devastating injuries at unprecedented rates. However, these patients can often face life threatening complications that stem from the robust innate immune response induced by severe hemorrhage, leading to further tissue injury rather than repair. The complement and coagulation cascades are key mediators in this disordered reaction, which includes the development of trauma-induced coagulopathy. There is increasing evidence that cross-talk between these two pathways allows rapid amplification of their otherwise targeted responses and contributes to overwhelming and prolonged systemic inflammation. In this article, we summarize the initial steps of innate immune response to trauma and review the complex complement and coagulation cascades, as well as how they interact with each other. Despite progress in understanding these cascades, effective therapeutic targets have yet to be found and further research is needed both to improve survival rates as well as decrease associated morbidity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.