ArticleBiomicrofluidics2019
Shear-induced platelet aggregation: 3D-grayscale microfluidics for repeatable and localized occlusive thrombosis.
Article in Biomicrofluidics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Platelet clotting defects in severe trauma identified by a whole blood microfluidic assay.Transfusion · 2026Article
- Applications of microfluidic chip technology in microvascular thrombosis research.Mikrochimica acta · 2025Review
- GPVI-mediated thrombus stabilization of shear-induced platelet aggregates in a microfluidic stenosis.Biophysical journal · 2025Article
- A Synergistic Overview between Microfluidics and Numerical Research for Vascular Flow and Pathological Investigations.Sensors (Basel, Switzerland) · 2024Review
- Material strengths of shear-induced platelet aggregation clots and coagulation clots.Scientific reports · 2024Article
- Advancing microfluidic point-of-care platelet function tests: opportunities and challenges from bench to market.Frontiers in bioengineering and biotechnology · 2024Review
- Why platelet mechanotransduction matters for hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2023Review
- Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model.Blood advances · 2022Article
- SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear.Blood advances · 2022Article
- An "occlusive thrombosis-on-a-chip" microfluidic device for investigating the effect of anti-thrombotic drugs.Lab on a chip · 2021Article
- Global Thrombosis Test: Occlusion by Coagulation or SIPA?TH open : companion journal to thrombosis and haemostasis · 2021Article
- Haemodynamic flow conditions at the initiation of high-shear platelet aggregation: a combinedInterface focus · 2021Article
- Article
- Development and Testing of Thrombolytics in Stroke.Journal of stroke · 2021Review
- Biorheology of occlusive thrombi formation under high shear: in vitro growth and shrinkage.Scientific reports · 2020Article
- Platelet α-granules are required for occlusive high-shear-rate thrombosis.Blood advances · 2020Article
- Getting a good view:Platelets · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherothrombosis leads to complications of myocardial infarction and stroke as a result of shear-induced platelet aggregation (SIPA). Clinicians and researchers may benefit from diagnostic and benchtop microfluidic assays that assess the thrombotic activity of an individual. Currently, there are several different proposed point-of-care diagnostics and microfluidic thrombosis assays with different design parameters and end points. The microfluidic geometry, surface coatings, and anticoagulation may strongly influence the precision of these assays. Variability in selected end points also persists, leading to ambiguous results. This study aims to assess the effects of three physiologically relevant extrinsic design factors on the variability of a single end point to provide a quantified rationale for design parameter and end-point standardization. Using a design of experiments approach, we show that the methods of channel fabrication and collagen surface coating significantly impact the variability of occlusion time from porcine whole blood, while anticoagulant selection between heparin and citrate did not significantly impact the variability. No factor was determined to significantly impact the mean occlusion time within the assay. Occlusive thrombus was found to consistently form in the first third (333
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Registered trials
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