ArticleChinese medicine2019
Metabolome and transcriptome analyses reveal quality change in the orange-rooted
Article in Chinese medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 35 citations in OpenAlex.
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- Transcriptomics and metabolomics revealed the molecular basis of the color formation in the roots ofHeliyon · 2024Article
- Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress.BMC plant biology · 2024Article
- Application of metabolomics in quality control of traditional Chinese medicines: a review.Frontiers in plant science · 2024Review
- Chromosome-level genome assembly ofHorticulture research · 2023Article
- Quality variation and biosynthesis of anti-inflammatory compounds forFrontiers in plant science · 2023Article
- Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis inInternational journal of molecular sciences · 2022Article
- Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials.Chinese medicine · 2022Review
- Integration of Transcriptome and Metabolome Provides New Insights to Flavonoids Biosynthesis inFrontiers in plant science · 2022Article
- Comparative transcriptome analyses of differentPeerJ · 2021Article
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- LC-MS-based multivariate statistical analysis for the screening of potential thrombin/factor Xa inhibitors from Radix Salvia Miltiorrhiza.Chinese medicine · 2020Article
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Authors and funding
20 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dry root and rhizome of
methodsMetabolome analysis was performed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-Tof-MS) to investigate the metabolites variation between orange Danshen and normal Danshen. RNA sequencing and KEGG enrichment analysis were performed to analyzing the differentially expressed genes between orange-rooted and normal Danshen.
resultsIn total, 40 lipophilic components were detected in metabolome analysis, and seven compounds were significantly decreased in the orange Danshen, including the most abundant active compounds, tanshinone IIA and tanshinone I in normal Danshen. Systematic analysis of transcriptome profiles revealed that the down-regulated genes related to catalytic dehydrogenation was not detected. However, two genes related to stress resistance, and four genes related to endoplasmic reticulum (ER)-associated degradation of proteins were up-regulated in orange Danshen.
conclusionsDecreases in the content of dehydrogenated furan ring tanshinones such as tanshinone IIA resulted in phenotypic changes and quality degradation of Danshen. Transcriptome analysis indicated that incorrect folding and ER-associated degradation of corresponding enzymes, which could catalyze C
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