Evidence map›Paper›PMID 31592210›Full record

ArticleJournal of clinical biochemistry and nutrition2019

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis.

Chuanlong Fan, Tao Huang, Xuejun Kong, Xiaohong Zhang, Zuquan Zou, Jing Xiao

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Chuanlong FanMedical School, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
Tao HuangDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, 5 Summer Palace Road, Haidian District, Beijing 100000, China.
Xuejun KongSynapse program/Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Xiaohong ZhangMedical School, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
Zuquan ZouMedical School, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China.
Jing XiaoBeijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xuanwu District, Beijing 100000, China.
Ningbo University · CNAthinoula A. Martinos Center for Biomedical Imaging · USBeijing Friendship Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although a large body of literature reported that high intake of vitamin E played a possible role in reducing risk of cardiometabolic diseases, conflicting results were also found in some observational studies due to confounding factors. Hence, we used a Mendelian randomization study as an alternative way to examine the causality between circulating vitamin E and cardiometabolic diseases. Summary-level data were extracted from consortia and three single nucleotide polymorphisms were used as instrumental variables. Our study showed that a one-SD increase in circulating vitamin E levels was causally associated with an increased risk of coronary artery disease [odds ratio (OR) 3.16 (95%CI 1.74, 5.73);

Indexed as

cardiometabolic diseasescoronary artery diseaselow density lipoprotein cholesterolMendelian randomizationvitamin E

Identifiers

PMID31592210
PMCPMC6769411
OpenAlexW2966900565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.