ArticleRSC advances2018
Click Chemistry Approaches to Expand the Repertoire of PEG-based Fluorinated Surfactants for Droplet Microfluidics.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Centrifugal Step-Emulsification Platform for High-Throughput Emulsion Screening.Small methods · 2026Article
- A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two-Step Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Non-Ionic Fluorosurfactants for Droplet-Based in vivo Applications.Angewandte Chemie (International ed. in English) · 2024Article
- Universal and Versatile Magnetic Connectors for Microfluidic Devices.Micromachines · 2024Article
- Resistivity detection of perfluoroalkyl substances with fluorous polyaniline in an electrical lateral flow sensor.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Magnetically functionalized hydrogels for high-throughput genomic applications.Advanced materials technologies · 2024Article
- Robust and rapid partitioning in thermoplastic.The Analyst · 2023Article
- Charge controlled interactions between DNA-modified silica nanoparticles and fluorosurfactants in microfluidic water-in-oil droplets.Nanoscale advances · 2023Article
- Optical pH Monitoring in Microdroplet Platforms for Live Cell Experiments Using Colloidal Surfactants.Methods in molecular biology (Clifton, N.J.) · 2023Article
- pH-Triggered Assembly of Endomembrane Multicompartments in Synthetic Cells.ACS synthetic biology · 2022Article
- Article
- Multi-layering of SU-8 exhibits distinct geometrical transitions from circular to planarized profiles.Biomicrofluidics · 2020Article
- DropSOAC: Stabilizing Microfluidic Drops for Time-Lapse Quantification of Single-Cell Bacterial Physiology.Frontiers in microbiology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
We report the novel and simplified synthesis of fluorinated surfactants for droplet microfluidics. The range of applications of droplet microfluidics has greatly expanded during the last decade thanks to its ability to manipulate and process tiny amount of sample and reagents at high throughput in independent reactors. A critical component of the technology is the formulation of the immiscible oil phase that contains surfactants to stabilize droplets. The success of droplet microfluidics relies mostly on a single fluorinated formulation that uses a PFPE-PEG tri-block surfactant. The synthesis of this surfactant is laborious and requires skills in synthetic chemistry preventing the wider community to explore the synthesis of alternate surfactants. We sought to provide a simplified synthesis for novel PFPE-PEG surfactants based on click chemistry approaches such as copper-catalyzed azide-alkyne cycloaddition (CuAAC) and UV-activated thiol-yne reactions. Our strategy is based on converting a moisture sensitive intermediate typically used in the synthesis of the tri-block PFPE-PEG surfactant into a stable and click ready molecule. We successfully combined that fluorinated tail with differently functionalized PEG and glycerol ethoxylate molecules to generate surfactants with diverse structures
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