ArticleCurrent opinion in behavioral sciences2019
The Conserved Transcriptional Response to Adversity.
Article in Current opinion in behavioral sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 172 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serious gaMe Come Interventi Emergenti di E-health Per i Giovani Con distuRbi neuroLogici o rEspiratori (SMILER) - Progetto@Cnr
Effects of Compassion-Based Resiliency Training (CBRT) Intervention on Racism-based Stress Among African Americans: A Pilot Study
Who cites it
172 citing papers in PubMed, 3 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Minority stress in relation to biological outcomes among sexual and gender minority people: a systematic review and update.Journal of behavioral medicine · 2025Pooled it
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Perceived Discrimination and Immunological Aging: A Systematic Review of Cellular and Molecular Markers.Biopsychosocial science and medicinePooled it
- An extraverted behavior intervention improves immune gene expression.Brain, behavior, and immunity · 2026Trial
- Trial
- Heart Rate Variability as a Digital Biomarker in Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation.Cancer medicine · 2025Trial
- Childhood Adversities and the ATTACHInternational journal of environmental research and public health · 2024Trial
- Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes.Journal of the National Cancer Institute · 2023Trial
- Attachment insecurity moderates emotion responses to mindfulness and loving-kindness meditation in adults raised in low socioeconomic status households.Emotion (Washington, D.C.) · 2022Trial
- Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Trial
- Beta-adrenergic blockade blunts inflammatory and antiviral/antibody gene expression responses to acute psychosocial stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Positive affect and inflammation in women with breast cancer: A systematic review.Brain, behavior, & immunity - health · 2026Review
- Curvilinear associations of discrimination attributions with inflammatory and antiviral gene expression.Psychoneuroendocrinology · 2026Article
- Transcriptomic signatures of mind-body transformations therapy in breast cancer: Downregulation of the interferon signaling pathway.Breast (Edinburgh, Scotland) · 2026Article
- Differential expression of lymphocyte markers by neighborhood opportunity among US adults: Insights from the Midlife in the United States study.Psychoneuroendocrinology · 2026Article
- Reconceptualizing Clinical Priority as Relational Influence: Derivation of Drawing Reasoning From a Sequential Programme of Research.Journal of evaluation in clinical practice · 2026Article
- Perceived everyday discrimination and leukocyte gene expression in a nationally representative sample of U.S. Adults.Brain, behavior, and immunity · 2026Article
- Built Environment Audits Across Space and Time for Estimating Time-Varying Exposures: Cohort Study.JMIR formative research · 2026Article
- Social Isolation, Genetic Susceptibility, Systemic Inflammation and Risk of Abdominal Aortic Aneurysm: A UK Biobank Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Associations among discrimination, genetic susceptibility to inflammation, and C-reactive protein.Brain, behavior, & immunity - health · 2026Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Gene expression profiling studies of people exposed to chronic threat have identified a Conserved Transcriptional Response to Adversity (CTRA) in circulating immune cells. This physiological pattern is characterized by up-regulated expression of genes involved in inflammation and down-regulated expression of genes involved in Type I interferon responses. The CTRA is mediated by beta-adrenergic signaling pathways that transduce sympathetic nervous system activity into changes in transcription factor activity and hematopoietic output of myeloid lineage immune cells (monocytes, neutrophils, and dendritic cells). Recent research has begun to identify the CNS processes that regulate peripheral CTRA activity, define its implications for disease, and explore the role of positive psychosocial factors in buffering such effects. The CTRA provides a genomic framework for understanding PNI relationships and connecting macro-level psychosocial processes to the micro-level biology of health and disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.