ArticleInternational journal of biological sciences2019
Influence of hyperproteinemia on reproductive development in an invertebrate model.
Article in International journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model.iScience · 2023Article
- Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model.Zoological research · 2022Article
- Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System inBiology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Hyperproteinemia is a severe metabolic disease characterized by abnormally elevated plasma protein concentrations (PPC). However, there is currently no reliable animal model for PPC, and the pathological mechanism of hyperproteinemia thus remains unclear. In this study, we evaluated the effects of hyperproteinemia on reproductive development in an invertebrate silkworm model with a controllable PPC and no primary disease effects. High PPC inhibited the synthesis of vitellogenin and 30K protein essential for female ovarian development in the fat body of metabolic tissues, and inhibited their transport through the hemolymph to the ovary. High PPC also induced programmed cell death in testis and ovary cells, slowed the development of germ cells, and significantly reduced the reproductive coefficient. Furthermore, the intensities and mechanisms of high-PPC-induced reproductive toxicity differed between sexes in this silkworm model.
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