Evidence map›Paper›PMID 31592021›Full record

ArticleHepatology communications2019

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA.

Jihane N Benhammou, Arthur Ko, Marcus Alvarez, Minna U Kaikkonen, Carl Rankin, Kristina M Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä and 3 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML.Cancer biomarkers : section A of Disease markers · 2023
    Article
  18. Review
  19. Enhancer RNA (eRNA) in Human Diseases.International journal of molecular sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jihane N BenhammouVatche and Tamar Manoukian Division of Digestive Diseases University of California Los Angeles Los Angeles CA.
Arthur KoDepartment of Medicine David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
Marcus AlvarezDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
Minna U KaikkonenInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland.
Carl RankinVatche and Tamar Manoukian Division of Digestive Diseases University of California Los Angeles Los Angeles CA.
Kristina M GarskeDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
David PaduaVatche and Tamar Manoukian Division of Digestive Diseases University of California Los Angeles Los Angeles CA.
Yash BhagatDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
Dorota KaminskaDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.ORCID https://orcid.org/0000-0003-1829-576X
Vesa KärjäDepartment of Clinical Pathology Kuopio University Hospital Kuopio Finland.
Jussi PihlajamäkiInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland.
Joseph R PisegnaDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
Päivi PajukantaDepartment of Human Genetics David Geffen School of Medicine at University of California Los Angeles Los Angeles CA.
University of California, Los Angeles · USUniversity of Eastern Finland · FIKuopio University Hospital · FI

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANTOR, RITA M. · 1985 to 2019
$50.2M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Genomics of dyslipidemia in MexicansR01HL095056 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAJUKANTA, PAIVI · 2009 to 2018
$5.9M
Integrating functional genomics in primary human adipocytes to investigate gene regulatory circuitry for obesogenic cardiovascular traitsF31HL142180 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARSKE, KRISTINA MARIE · 2018 to 2020
$110k
NHLBI NIH HHS F31 HL142180NHLBI NIH HHS P01 HL028481NHLBI NIH HHS R01 HL095056NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

The global obesity epidemic is driving the concomitant rise in nonalcoholic fatty liver disease (NAFLD). To identify new genes involved in central liver functions, we examined liver RNA-sequence data from 259 patients who underwent morbidly obese bariatric surgery. Of these patients, 84 had normal liver histology, 40 simple steatosis, 43 nonalcoholic steatohepatitis, and the remaining 92 patients had varying degrees of NAFLD based on liver histology. We discovered oligodendrocyte maturation-associated long intergenic noncoding RNA (

Identifiers

PMID31592021
PMCPMC6771395
OpenAlexW2968085309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.