Evidence map›Paper›PMID 31591965›Full record

ArticleeLife2019

Olfactory connectivity mediates sleep-dependent food choices in humans.

Surabhi Bhutani, James D Howard, Rachel Reynolds, Phyllis C Zee, Jay Gottfried, Thorsten Kahnt

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04179838 (Olfactory Contributions to Sleep-dependent Food Craving and Calorie Intake), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04179838 nacompletednot on this map

Olfactory Contributions to Sleep-dependent Food Craving and Calorie Intake

TypeinterventionalSponsorNorthwestern UniversityRan2016 to 2017Enrolled29ConditionsSleep DeprivationArmsSleep-Deprived, Non-Sleep Deprived
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Characterizing Olfactory Brain Responses in Young Infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Olfactory Performance among Hospital Residents.International archives of otorhinolaryngology · 2022
    Article
  13. Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022
    Review
  14. On the state-dependent nature of odor perception.Frontiers in neuroscience · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Surabhi BhutaniDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
James D HowardDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-9309-3773
Rachel ReynoldsDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
Phyllis C ZeeDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
Jay GottfriedDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
Thorsten KahntDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-3575-2670
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Principles of olfactory reward processing in the human brainR01DC015426 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZELANO, CHRISTINA MARIA · 2016 to 2025
$4.4M
Olfactory contributions to sleep-dependent food craving and calorie intakeR21DK118503 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAHNT, THORSTEN · 2019 to 2020
$442k
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS T32 HL007909NIA NIH HHS P01 AG011412NIDCD NIH HHS R01 DC015426NIDDK NIH HHS R21 DK118503
6 · The paper itself

Abstract

Sleep deprivation has marked effects on food intake, shifting food choices toward energy-dense options. Here we test the hypothesis that neural processing in central olfactory circuits, in tandem with the endocannabinoid system (ECS), plays a key role in mediating this relationship. We combined a partial sleep-deprivation protocol, pattern-based olfactory neuroimaging, and

Indexed as

Food PreferencesSleepAdultCerebral CortexFemaleGlyceridesHumansMaleNeuroimagingOlfactory PathwaysPiriform CortexSleep DeprivationSmellYoung Adult2-oleoylglycerolGlyceridesfMRIfood intakehumanneuroscienceolfactionsleep deprivation

Identifiers

PMID31591965
PMCPMC6783266
OpenAlexW2980316252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.