Evidence map›Paper›PMID 31591963›Full record

ArticleeLife2019

Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms.

Yoseop Yoon, Jeff Klomp, Ines Martin-Martin, Frank Criscione, Eric Calvo, Jose Ribeiro, Urs Schmidt-Ott

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  5. Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025
    Article
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  7. Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yoseop YoonDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, United States.ORCID 0000-0002-6062-0979
Jeff KlompDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, United States.
Ines Martin-MartinLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, United States.
Frank CriscioneLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, United States.
Eric CalvoLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, United States.
Jose RibeiroLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, United States.
Urs Schmidt-OttDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, United States.ORCID 0000-0002-1351-9472
Vector (United States) · USUniversity of Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Genetic variation and function of body axis determinants in midges and other fliesR01GM127366 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHMIDT-OTT, URS C · 2018 to 2025
$2.3M
NCATS NIH HHS UL1 TR000430NIGMS NIH HHS R01 GM127366NIGMS NIH HHS R01 GM127366-01A1
6 · The paper itself

Abstract

Unrelated genes establish head-to-tail polarity in embryos of different fly species, raising the question of how they evolve this function. We show that in moth flies (

Indexed as

Body PatterningGene Expression Regulation, DevelopmentalTranscription, GeneticAnimalsEmbryonic DevelopmentEmbryo, NonmammalianInsect ProteinsProtein IsoformsPsychodidaeInsect ProteinsProtein Isoformsalternative polyadenylationalternative promoteraxis specificationbicoiddevelopmental biologyD. melanogasterevolutionary biologymosquitoespangolin

Identifiers

PMID31591963
PMCPMC6783274
OpenAlexW2979667276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.