Evidence map›Paper›PMID 31591901›Full record

ArticleBrain connectivity2019

Intrinsic Functional Connectivity of Dentate Nuclei in Autism Spectrum Disorder.

Sheeba Arnold Anteraper, Xavier Guell, Hoyt Patrick Taylor, Anila D'Mello, Susan Whitfield-Gabrieli, Gagan Joshi

Open access · greenAbstract read
In one paragraph

Article in Brain connectivity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Sheeba Arnold AnteraperAlan and Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorder, Massachusetts General Hospital, Boston, Massachusetts.
Xavier GuellDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Hoyt Patrick TaylorDepartment of Physics, University of North Carolina, Chapel Hill, North Carolina.
Anila D'MelloDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Susan Whitfield-GabrieliDepartment of Psychology, Northeastern University, Boston, Massachusetts.
Gagan JoshiAlan and Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorder, Massachusetts General Hospital, Boston, Massachusetts.
Massachusetts Institute of Technology · USHarvard University · USMassachusetts General Hospital · USNortheastern University · USUniversity of North Carolina at Chapel Hill · US

Funding

Characterizing Neural Adaptation in Autism Spectrum DisorderF32MH117933 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DMELLO, ANILA · 2018 to 2022
$222k
6 · The paper itself

Abstract

Cerebellar abnormalities are commonly reported in autism spectrum disorder (ASD). Dentate nuclei (DNs) are key structures in the anatomical circuits linking the cerebellum to the extracerebellum. Previous resting-state functional connectivity (RsFc) analyses reported DN abnormalities in high-functioning ASD (HF-ASD). This study examined the RsFc of the DN in young adults with HF-ASD compared with healthy controls (HCs) with the aim to expand upon previous findings of DNs in a dataset using advanced, imaging acquisition methods that optimize spatiotemporal resolution and statistical power. Additional seed-to-voxel analyses were carried out using motor and nonmotor DN coordinates reported in previous studies as seeds. We report abnormal dentato-cerebral and dentato-cerebellar functional connectivity in ASD. Our results expand and, in part, replicate previous descriptions of DN RsFc abnormalities in this disorder and reveal correlations between DN-cerebral RsFc and ASD symptom severity.

Indexed as

AdolescentAdultAutism Spectrum DisorderBrainBrain MappingCerebellar NucleiCerebellumCerebral CortexConnectomeHumansMagnetic Resonance ImagingMaleNeural PathwaysRestYoung Adultautism spectrum disordercerebellumdentate nucleusfunctional connectivityresting state networkssocial cognition

Identifiers

PMID31591901
PMCPMC7058992
OpenAlexW2980182850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.