Evidence map›Paper›PMID 31591788›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2020

Neural crest development: insights from the zebrafish.

Manuel Rocha, Noor Singh, Kamil Ahsan, Anastasia Beiriger, Victoria E Prince

Open access · bronzeAbstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 108 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
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  6. Article
  7. A thermodynamic perspective on mammalian neural crest ingression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
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  10. Article
  11. Review
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  14. foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  15. Article
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  17. Review
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  19. Article
  20. Blocking endogenous retinoic acid degradation induces oral tooth formation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Manuel RochaCommittee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, Illinois.
Noor SinghDepartment of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois.
Kamil AhsanCommittee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, Illinois.
Anastasia BeirigerCommittee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, Illinois.
Victoria E PrinceCommittee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, Illinois.ORCID 0000-0001-5810-7300
University of Chicago · US

Funding

Training Program in Developmental BiologyT32HD055164 · NICHD · UNIVERSITY OF CHICAGO · PI Sally Horne-Badovinac, Paschalis Kratsios · 2008 to 2026
$3.6M
The role of Cdx factors in zebrafish neural crest regionalizationF31HD097957 · NICHD · UNIVERSITY OF CHICAGO · PI ROCHA, MANUEL · 2018 to 2020
$129k
NICHD NIH HHS F31 HD097957NICHD NIH HHS T32 HD055164
6 · The paper itself

Abstract

Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of multiple model organisms. Early research on neural crest cells (NCCs) was dominated by analyses of accessible amphibian and avian embryos, with mouse genetics providing complementary insights in more recent years. The zebrafish model is a relative newcomer to the field, yet it offers unparalleled advantages for the study of NCCs. Specifically, zebrafish provide powerful genetic and transgenic tools, coupled with rapidly developing transparent embryos that are ideal for high-resolution real-time imaging of the dynamic process of neural crest development. While the broad principles of neural crest development are largely conserved across vertebrate species, there are critical differences in anatomy, morphogenesis, and genetics that must be considered before information from one model is extrapolated to another. Here, our goal is to provide the reader with a helpful primer specific to neural crest development in the zebrafish model. We focus largely on the earliest events-specification, delamination, and migration-discussing what is known about zebrafish NCC development and how it differs from NCC development in non-teleost species, as well as highlighting current gaps in knowledge.

Indexed as

AnimalsCell MovementEpithelial-Mesenchymal TransitionNeural CrestZebrafishZebrafish ProteinsZebrafish Proteinscell migrationepithelial-to-mesenchymal transitionneural crestzebrafish

Identifiers

PMID31591788
PMCPMC7273345
OpenAlexW2980181133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.