Evidence map›Paper›PMID 31591654›Full record

ArticleSurgical endoscopy2020

Fluorescence-based cholangiography: preliminary results from the IHU-IRCAD-EAES EURO-FIGS registry.

Vincent Agnus, Antonio Pesce, Luigi Boni, Jacqueline Van Den Bos, Salvador Morales-Conde, Alessandro M Paganini, Silvia Quaresima, Andrea Balla, Gaetano La Greca, Haralds Plaudis and 10 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04863482 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Safety of Laparoscopic ChOlecystectomy Performed by Trainee Surgeons With Different CHolangiographic Techniques

TypeinterventionalSponsorUniversità Politecnica delle MarcheRan2021 to 2021Enrolled1,500ConditionsCholecystitis, GallstoneArmsIOC
NCT05419947 phase4completednot on this mapstarted 2022, after this paper: background citation

Randomized Clinical Trial for the Optimization of Indocyanine Green Administration in Near-infrared Fluorescent Cholangiography During Laparoscopic Cholecystectomy.

TypeinterventionalSponsorFundación Instituto de Estudios de Ciencias de la Salud de Castilla y LeónRan2022 to 2023Enrolled200ConditionsLaparoscopic CholecystectomyArmsVERDYE powder for solution for injection 25 mg
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  16. Indocyanine green: The guide to safer and more effective surgery.World journal of gastrointestinal surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 6 countries.

Vincent AgnusIHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France.
Antonio PesceDepartment of Medical Surgical Sciences and Advanced Technologies "Ingrassia", Cannizzaro Hospital, University of Catania, Catania, Italy.
Luigi BoniDepartment of Surgery, IRCCS - Ca' Granda - University Hospital of Milan, Milan, Italy.
Jacqueline Van Den BosDepartment of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Salvador Morales-CondeUnit of Innovation in Minimally Invasive Surgery, Department of General and Digestive Surgery, University Hospital "Virgen del Rocio", University of Seville, Seville, Spain.
Alessandro M PaganiniObesity and Minimally Invasive Surgery Division, Department of Cardiothoracic, Vascular Surgery, and Organ Transplantation, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Silvia QuaresimaObesity and Minimally Invasive Surgery Division, Department of Cardiothoracic, Vascular Surgery, and Organ Transplantation, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Andrea BallaObesity and Minimally Invasive Surgery Division, Department of Cardiothoracic, Vascular Surgery, and Organ Transplantation, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Gaetano La GrecaDepartment of Medical Surgical Sciences and Advanced Technologies "Ingrassia", Cannizzaro Hospital, University of Catania, Catania, Italy.
Haralds PlaudisDepartment of General and Emergency Surgery, Riga East Clinical University Hospital "Gailezers", Riga, Latvia.
Gianluigi MorettoDepartment of General Surgery, Ospedale Pederzoli, Peschiera del Garda, Verona, Italy.
Maurizio CastagnolaEnte Ospedaliero Ospedali Galliera, Genoa, Italy.
Caterina SantiAzienda Unità Sanitaria Locale di Parma, Ospedale di Fidenza, Parma, Italy.
Lorenzo CasaliAzienda Unità Sanitaria Locale di Parma, Ospedale di Fidenza, Parma, Italy.
Luciano TartamellaAzienda Unità Sanitaria Locale di Parma, Ospedale di Fidenza, Parma, Italy.
Alend SaadiDepartment of General Surgery, Hospital of Pourtalès, Neuchâtel, Switzerland.
Andrea PicchettoGeneral and Colorectal Surgery Division, Department of Cardiothoracic, Vascular Surgery and Organ Transplantation, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Alberto ArezzoDepartment of Surgical Sciences, University of Torino, Turin, Italy.
Jacques MarescauxIHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France.
Michele DianaIHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France. michele.diana@ircad.fr.ORCID 0000-0002-1390-8486
Policlinico Umberto I · ITAzienda Unita' Sanitaria Locale di Parma · ITHospital Neuchâtel · CHUniversity of Catania · ITEnte Ospedaliero Ospedali Galliera · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITInstitut de Chirurgie Guidée par l'Image · FRInstitut de Recherche contre les Cancers de l’Appareil Digestif · FRInstituto de Biomedicina de Sevilla · ESMaastricht University · NLRiga East University Hospital · LVUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNear-infrared fluorescence cholangiography (NIRF-C) is a popular application of fluorescence image-guided surgery (FIGS). NIRF-C requires near-infrared optimized laparoscopes and the injection of a fluorophore, most frequently Indocyanine Green (ICG), to highlight the biliary anatomy. It is investigated as a tool to increase safety during cholecystectomy. The European registry on FIGS (EURO-FIGS: www.euro-figs.eu ) aims to obtain a snapshot of the current practices of FIGS across Europe. Data on NIRF-C are presented.

methodsEURO-FIGS is a secured online database which collects anonymized data on surgical procedures performed using FIGS. Data collected for NIRF-C include gender, age, Body Mass Index (BMI), pathology, NIR device, ICG dose, ICG timing of administration before intraoperative visualization, visualization (Y/N) of biliary structures such as the cystic duct (CD), the common bile duct (CBD), the CD-CBD junction, the common hepatic duct (CHD), Visualization scores, adverse reactions to ICG, operative time, and surgical complications.

resultsFifteen surgeons (12 European surgical centers) uploaded 314 cases of NIRF-C during cholecystectomy (cholelithiasis n = 249, cholecystitis n = 58, polyps n = 7), using 4 different NIR devices. ICG doses (mg/kg) varied largely (mean 0.28 ± 0.17, median 0.3, range: 0.02-0.62). Similarly, injection-to-visualization timing (minutes) varied largely (mean 217 ± 357; median 57), ranging from 1 min (direct intragallbladder injection in 2 cases) to 3120 min (n = 2 cases). Visualization scores before dissection were significantly correlated, at univariate analysis, with ICG timing (all structures), ICG dose (CD-CBD), device (CD and CD-CBD), surgeon (CD and CD-CBD), and pathology (CD and CD-CBD). BMI was not correlated. At multivariate analysis, pathology and timing remained significant factors affecting the visualization scores of all three structures, whereas ICG dose remained correlated with HD visualization only.

conclusionsThe EURO-FIGS registry has confirmed a wide disparity in ICG dose and timing in NIRF-C. EURO-FIGS can represent a valuable tool to promote and monitor FIGS-related educational and consensus activities in Europe.

Indexed as

CholangiographyRegistriesSurgery, Computer-AssistedCholecystectomyCholecystitisCholelithiasisEuropeFemaleFluorescenceHumansIndocyanine GreenLinear ModelsMaleMiddle AgedMultivariate AnalysisIndocyanine GreenFluorescence-guided surgeryImage-guided surgeryNear-infrared fluorescence cholangiographyRegistry

Identifiers

PMID31591654
OpenAlexW2979511288

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.