Trial reportEuropean journal of nutrition2020
A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males.
Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022Pooled it
- The impact of antioxidants on antioxidant capacity, DNA fragmentation, and chromatin quality in subfertile men: a randomized clinical trial study.Revista da Associacao Medica Brasileira (1992) · 2024Trial
- The critical role of oxidative stress in male infertility: causes, diagnostic biomarkers, and the efficacy of antioxidant therapy.Molecular biology reports · 2026Review
- The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications.Antioxidants (Basel, Switzerland) · 2025Review
- Lycopene in male infertility.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Advancements in Understanding and Enhancing Antioxidant-Mediated Sperm Cryopreservation in Small Ruminants: Challenges and Perspectives.Antioxidants (Basel, Switzerland) · 2024Review
- Lycopene protects against ionizing radiation-induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction.Food science & nutrition · 2024Article
- Dietary trends and the decline in male reproductive health.Hormones (Athens, Greece) · 2023Review
- Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia.Food science & nutrition · 2022Article
- Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation.Biology · 2022Review
- Toxicity of Antioxidant Supplements in Patients with Male Factor Infertility: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Antioxidants (Basel, Switzerland) · 2021Review
- Lycopene protects sperm from oxidative stress in the experimental varicocele model.Food science & nutrition · 2021Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
- Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence.The world journal of men's health · 2021Review
- Effectiveness of Pharmacological Intervention Among Men with Infertility: A Systematic Review and Network Meta-Analysis.Frontiers in pharmacology · 2021Article
- Reply to the letter: Lycopene improves sperm motility and morphology: a promising agent for treating male infertility.European journal of nutrition · 2020Article
- Lycopene improves sperm motility and morphology: a promising agent for treating male infertility.European journal of nutrition · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePoor sperm quality is a major contributor to infertility in heterosexual couples, but at present there are few empirical therapies. Several studies have examined the role of dietary factors and data from randomized controlled trials suggest that oral antioxidant therapy can improve some sperm parameters. Health benefits of lycopene supplementation have been proposed for a variety of health conditions and here we examine whether it can help improve sperm quality. This study aimed to investigate the effect of 14 mg daily lactolycopene for 12 weeks on semen quality in healthy men.
methodsSixty healthy male participants were recruited and randomized to this double-blind, placebo-controlled parallel study and received either 14 mg/d lactolycopene or a placebo for 12 weeks. The primary endpoint was a change in motile sperm concentration. Secondary endpoints were all other aspects of sperm quality, including the level of sperm DNA damage.
resultsFifty-six men completed the intervention and the level of plasma lycopene was significantly increased in the men randomized to receive lycopene supplementation. There was no significant change in the primary endpoint (motile sperm concentration) post-intervention (p = 0.058). However, the proportion of fast progressive sperm (p = 0.006) and sperm with normal morphology (p < 0.001) did improve significantly in response to lactolycopene intervention.
conclusionsSupplementation with 14 mg/d lactolycopene improves sperm motility and morphology in young healthy men. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE: ISRCTN33248724 http://www.isrctn.com/ISRCTN33248724.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.