ArticleNature medicine2019
Single-cell immune landscape of human atherosclerotic plaques.
2 registry-linked trialsAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 641 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
641citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Exploratory, Cohort Clinical Study Comparing the Effects of Oral Statins With or Without Folic Acid on Carotid Plaque Stability.
PMID 25175924PMID 11877368PMID 17118406PMID 19201496PMID 21067804PMID 22209480PMID 22606998PMID 25103444PMID 25771069PMID 28475143PMID 29549174PMID 29765016other papers from this trial
Open the trial in the graphThe Architectural Immunoregulation in Atherosclerotic Disease: A Single-Cell RNA Sequencing and Spatial Biology Approach
Who cites it
641 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.International journal of molecular sciences · 2026Pooled it
- Pooled it
- Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.Renal failure · 2026Article
- BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review).Molecular medicine reports · 2026Review
- ATP Inside and Out: Understanding Atherosclerosis Through Energy Metabolism and Purinergic Signaling.Journal of atherosclerosis and thrombosis · 2026Review
- Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Roles of inflammation and metabolic dysfunction in cardiovascular diseases: molecular mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Article
- Inflammation as a therapeutic target to improve kidney and cardiovascular outcomes.Nature reviews. Nephrology · 2026Review
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Reversing the pipeline: a 'human-first' multi-omics approach to cardiovascular discovery.Experimental & molecular medicine · 2026Review
- A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis.Autophagy · 2026Article
- Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis.Journal of cell communication and signaling · 2026Article
- Berberine-associated lipid-inflammatory regulation in atherosclerosis: an integrative transcriptomic, single-cell, and in vivo study.Functional & integrative genomics · 2026Article
- Mitochondrial Redox Failure Links Senescence-like Foam Cell Stress to Ferroptosis and Plaque Non-Resolution in Atherosclerosis.Antioxidants (Basel, Switzerland) · 2026Review
- Review
- Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer.Acta pharmacologica Sinica · 2026Article
- Copper-Doped Prussian Blue Nanozymes With Hyaluronic Acid-Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies.Immunological reviews · 2026Review
- Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.Nature cell biology · 2026Article
581 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors.
Dawn M FernandezCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adeeb H RahmanThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicolas F FernandezHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aleksey ChudnovskiyThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
El-Ad David AmirHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Letizia AmadoriDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nayaab S KhanCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christine K WongCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roza ShamailovaCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3749-4556
Christopher A HillCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zichen WangMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1415-1286
Romain RemarkThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jennifer R LiDepartment of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christian PinaDepartment of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christopher FariesDepartment of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ahmed J AwadCerebrovascular Center, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Noah MossCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Johan L M BjorkegrenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-1945-7425
Seunghee Kim-SchulzeThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sacha GnjaticThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5643-9520
Avi Ma'ayanMount Sinai Center for Bioinformatics, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6904-1017
J MoccoCerebrovascular Center, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter FariesDepartment of Surgery, Vascular Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miriam MeradThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chiara GiannarelliCardiovascular Research Center, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. chiara.giannarelli@mssm.edu.ORCID http://orcid.org/0000-0003-2473-6058
Funding
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4MData Coordination and Integration Center for LINCS-BD2KU54HL127624 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SCHURER, STEPHAN C · 2014 to 2019
$23.5MHigh-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5MTRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6MToward Diagnostics and Therapies of Molecular Subcategories of CADR01HL125863 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BJORKEGREN, JOHAN M · 2015 to 2018
$3.2MNovel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disesaseU24AI118644 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERIN, CECILIA, MERAD, MIRIAM · 2015 to 2020
$2.4MKnowledge Management Center for Illuminating the Druggable GenomeU24CA224260 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2018 to 2023
$1.5MRole of alternatively spliced Tissue Factor in atherosclerosisK23HL111339 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2013 to 2017
$782kNetwork-driven drug repurposing approaches to treat coronary artery diseaseR21TR001739 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BJORKEGREN, JOHAN M, GIANNARELLI, CHIARA · 2016 to 2017
$678kSingle-cell-driven drug repositioning approaches to target inflammation in atherosclerosisUH2TR002067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2017 to 2018
$678kHelios Mass CytometerS10OD023547 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAHMAN, ADEEB HABIBUR · 2017 to 2017
$667kDissecting the cellular and molecular immune interactions in human atherosclerosisR03HL135289 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GIANNARELLI, CHIARA · 2016 to 2017
$170kNCATS NIH HHS R21 TR001739NCATS NIH HHS UH2 TR002067NCI NIH HHS U24 CA224260NCI NIH HHS U24 CA224319NHLBI NIH HHS K23 HL111339NHLBI NIH HHS R01 HL125863NHLBI NIH HHS R03 HL135289NHLBI NIH HHS T32 HL007824NHLBI NIH HHS U54 HL127624NIAID NIH HHS U19 AI128949NIAID NIH HHS U24 AI118644NIH HHS S10 OD023547
Abstract
Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. However, specific characteristics of dysregulated immune cells within atherosclerotic lesions that lead to clinical events such as ischemic stroke or myocardial infarction are poorly understood. Here, using single-cell proteomic and transcriptomic analyses, we uncovered distinct features of both T cells and macrophages in carotid artery plaques of patients with clinically symptomatic disease (recent stroke or transient ischemic attack) compared to asymptomatic disease (no recent stroke). Plaques from symptomatic patients were characterized by a distinct subset of CD4
Indexed as
Single-Cell AnalysisAdaptive ImmunityAgedAtherosclerosisCell DifferentiationEndarterectomy, CarotidFemaleHumansImmunity, InnateInterleukin-1betaLeukocytes, MononuclearMacrophagesMalePlaque, AtheroscleroticProteomeSignal TransductionInterleukin-1betaProteome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT07680595ClinicalTrials.gov
NCT06860295ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.