Evidence map›Paper›PMID 31591574›Full record

ArticleNature immunology2019

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang and 8 more

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Xcr1eLife · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. LAG-3-An incompletely understood target in cancer therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Embracing complexity in sepsis.Critical care (London, England) · 2023
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Guillaume VoisinneCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.ORCID http://orcid.org/0000-0003-3922-2121
Kristof KersseCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Karima ChaouiInstitut de Pharmacologie et de Biologie Structurale, Département Biologie Structurale Biophysique, Protéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089, Toulouse, France.
Liaoxun LuSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Julie ChaixCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Lichen ZhangSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Marisa Goncalves MenoitaCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Laura GirardCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Youcef OunougheneCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Hui WangSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Odile Burlet-SchiltzInstitut de Pharmacologie et de Biologie Structurale, Département Biologie Structurale Biophysique, Protéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089, Toulouse, France.
Hervé LucheCentre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, Marseille, France.
Frédéric FioreCentre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, Marseille, France.
Marie MalissenCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Anne Gonzalez de PeredoInstitut de Pharmacologie et de Biologie Structurale, Département Biologie Structurale Biophysique, Protéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089, Toulouse, France.ORCID http://orcid.org/0000-0001-6152-6311
Yinming LiangSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China. yinming.liang@foxmail.com.ORCID http://orcid.org/0000-0001-9174-4037
Romain RoncagalliCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France. roncagalli@ciml.univ-mrs.fr.ORCID http://orcid.org/0000-0001-7554-0552
Bernard MalissenCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France. bernardm@ciml.univ-mrs.fr.ORCID http://orcid.org/0000-0003-1340-9342
Centre National de la Recherche Scientifique · FRXinxiang Medical University · CNXinxiang University · CN

Funding

European Research Council 322465European Research Council 787300
6 · The paper itself

Abstract

The activation of T cells by the T cell antigen receptor (TCR) results in the formation of signaling protein complexes (signalosomes), the composition of which has not been analyzed at a systems level. Here, we isolated primary CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesChromatography, AffinityMass SpectrometryMiceMice, TransgenicPrimary Cell CultureProtein Interaction MappingProtein Interaction MapsReceptors, Antigen, T-CellSignal TransductionReceptors, Antigen, T-Cell

Identifiers

PMID31591574
PMCPMC6859066
OpenAlexW2978261781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.