Evidence map›Paper›PMID 31591570›Full record

ArticleNature immunology2019

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation.

Andrew J M Howden, Jens L Hukelmann, Alejandro Brenes, Laura Spinelli, Linda V Sinclair, Angus I Lamond, Doreen A Cantrell

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 237 citations in OpenAlex.

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  15. Translational Downregulation of 5' TOP mRNAs During T Cell Exhaustion.bioRxiv : the preprint server for biology · 2025
    Article
  16. Iron and the immune system.Nature reviews. Immunology · 2025
    Review
  17. Article
  18. Review
  19. Immunometabolic Targets in CD8Liver cancer · 2025
    Review
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew J M HowdenCell Signalling and Immunology, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-4332-9469
Jens L HukelmannCentre for Gene Regulation and Expression, University of Dundee, Dundee, UK.
Alejandro BrenesCentre for Gene Regulation and Expression, University of Dundee, Dundee, UK.
Laura SpinelliCell Signalling and Immunology, University of Dundee, Dundee, UK.
Linda V SinclairCell Signalling and Immunology, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0003-1248-7189
Angus I LamondCentre for Gene Regulation and Expression, University of Dundee, Dundee, UK. a.i.lamond@dundee.ac.uk.ORCID http://orcid.org/0000-0001-6204-6045
Doreen A CantrellCell Signalling and Immunology, University of Dundee, Dundee, UK. d.a.cantrell@dundee.ac.uk.ORCID http://orcid.org/0000-0001-7525-3350
University of Dundee · GB

Funding

Wellcome TrustWellcome Trust 105024Wellcome Trust 202950Wellcome Trust 205023Wellcome Trust 205023/Z/16/Z
6 · The paper itself

Abstract

Quantitative mass spectrometry reveals how CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Cycle CheckpointsCell DifferentiationCells, CulturedFemaleGene DosageGene Expression ProfilingGene Expression RegulationMaleMass SpectrometryMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicProteomeMechanistic Target of Rapamycin Complex 1ProteomeSirolimus

Identifiers

PMID31591570
PMCPMC6859072
OpenAlexW2977451996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.