ArticleNature neuroscience2019
Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Differences in interactions between brain regions across personality types while learning in zebrafish (bioRxiv : the preprint server for biology · 2026Article
- Representational learning by optimization of neural manifolds in an olfactory memory network.Nature neuroscience · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Article
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.Current biology : CB · 2024Article
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Altered fear engram encoding underlying conditioned versus unconditioned stimulus-initiated memory updating.Science advances · 2023Article
- Learning-dependent structural plasticity of intracortical and sensory connections to functional domains of the olfactory tubercle.Frontiers in neuroscience · 2023Article
- Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.Neuron · 2022Article
- Article
- A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging.Nature neuroscience · 2021Article
- Learning-dependent neuronal activity across the larval zebrafish brain.Current opinion in neurobiology · 2021Review
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.eLife · 2020Article
- A virtual reality system to analyze neural activity and behavior in adult zebrafish.Nature methods · 2020Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Intelligent behavior involves associations between high-dimensional sensory representations and behaviorally relevant qualities such as valence. Learning of associations involves plasticity of excitatory connectivity, but it remains poorly understood how information flow is reorganized in networks and how inhibition contributes to this process. We trained adult zebrafish in an appetitive odor discrimination task and analyzed odor representations in a specific compartment of the posterior zone of the dorsal telencephalon (Dp), the homolog of mammalian olfactory cortex. Associative conditioning enhanced responses with a preference for the positively conditioned odor. Moreover, conditioning systematically remapped odor representations along an axis in coding space that represented attractiveness (valence). Interindividual variations in this mapping predicted variations in behavioral odor preference. Photoinhibition of interneurons resulted in specific modifications of odor representations that mirrored effects of conditioning and reduced experience-dependent, interindividual variations in odor-valence mapping. These results reveal an individualized odor-to-valence map that is shaped by inhibition and reorganized during learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.