ArticleNature nanotechnology2019
Rectification of protein translocation in truncated pyramidal nanopores.
Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stress-induced ripping enables fabrication of nanopores with dimensions smaller than the resolution limit of the employed lithography.Science advances · 2026Article
- Directional Single-Protein Transport Enabled by 2D Material Heterointerfaces in Solid-State Nanopores: Implications for Single-Molecule Sensing.ACS applied nano materials · 2026Article
- Investigation on fabrication of silicon nanopores using an electrochemical passivation etch-stop strategy.Microsystems & nanoengineering · 2025Article
- Angular-Inertia Regulated Stable and Nanoscale Sensing of Single Molecules Using Nanopore-In-A-Tube.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Brownian Motion Paving the Way for Molecular Translocation in Nanopores.Small methods · 2024Article
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules.Nature communications · 2024Article
- Solid-State Nanopores for Biomolecular Analysis and Detection.Advances in biochemical engineering/biotechnology · 2024Review
- Study on the controllability of the fabrication of single-crystal silicon nanopores/nanoslits with a fast-stop ionic current-monitored TSWE method.Microsystems & nanoengineering · 2023Article
- A Generalized Transformer-Based Pulse Detection Algorithm.ACS sensors · 2022Article
- Docking and Activity of DNA Polymerase on Solid-State Nanopores.ACS sensors · 2022Article
- Label-Free Optical Analysis of Biomolecules in Solid-State Nanopores: Toward Single-Molecule Protein Sequencing.ACS photonics · 2022Review
- A Guide to Signal Processing Algorithms for Nanopore Sensors.ACS sensors · 2021Article
- Article
- Vibrational Spectra of Nucleotides in the Presence of the Au Cluster Enhancer in MD Simulation of a SERS Sensor.Biosensors · 2021Article
- Biological Nanopores: Engineering on Demand.Life (Basel, Switzerland) · 2021Review
- Dynamics of DNA Clogging in Hafnium Oxide Nanopores.The journal of physical chemistry. B · 2020Article
- Pore Structures for High-Throughput Nanopore Devices.Micromachines · 2020Article
- Electro-Osmotic Vortices Promote the Capture of Folded Proteins by PlyAB Nanopores.Nano letters · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid-state nanopore technology presents an emerging single-molecule-based analytical tool for the separation and analysis of nanoparticles. Different approaches have been pursued to attain the anticipated detection performance. Here, we report the rectification behaviour of protein translocation through silicon-based truncated pyramidal nanopores. When the size of translocating proteins is comparable to the smallest physical constriction of the nanopore, the frequency of translocation events observed is lower for proteins that travel from the larger to the small opening of the nanopore than for those that travel in the reverse direction. When the proteins are appreciably smaller than the nanopore, an opposite rectification in the frequency of translocation events is evident. The maximum rectification factor achieved is around ten. Numerical simulations reveal the formation of an electro-osmotic vortex in such asymmetric nanopores. The vortex-protein interaction is found to play a decisive role in rectifying the translocation in terms of polarity and amplitude. The reported phenomenon can be potentially exploitable for the discrimination of various nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.