ArticleNature human behaviour2019
Identification of neurobehavioural symptom groups based on shared brain mechanisms.
Abstract read
In one paragraph
Article in Nature human behaviour, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of transcranial direct current stimulation for children and adolescents with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies.Molecular psychiatry · 2026Review
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Modeling psychopathology in high-dimensional vector space using the high-dimensional symptom space (HDSS) model can operationalize precision psychiatry in US adolescents.Scientific reports · 2025Article
- Interpretable and integrative deep learning for discovering brain-behaviour associations.Scientific reports · 2025Article
- Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis.bioRxiv : the preprint server for biology · 2024Article
- Multimodal integrated flexible neural probe forRSC advances · 2024Article
- [The German Center for Mental Health : Innovative translational research to promote prevention, targeted intervention and resilience].Der Nervenarzt · 2024Review
- Evaluation of behavioral variance/covariance explained by the neuroimaging data through a pattern-based regression.Human brain mapping · 2024Article
- Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample.Network neuroscience (Cambridge, Mass.) · 2024Article
- Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children.Developmental cognitive neuroscience · 2023Article
- Within-network brain connectivity during a social optimism task is related to personal optimism and optimism for in-group members.Human brain mapping · 2023Article
- A Fast and Minimal System to Identify Depression Using Smartphones: Explainable Machine Learning-Based Approach.JMIR formative research · 2023Article
- Article
- Functional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies.Molecular psychiatry · 2023Article
- Effects of urban living environments on mental health in adults.Nature medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
51 authors.
Alex IngCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Philipp G SämannNeuroimaging, Max Planck Institute of Psychiatry, Munich, Germany.
Congying ChuCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Nicole TayCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1307-408X
Francesca BiondoCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0001-9952-0249
Gabriel RobertCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Tianye JiaCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5399-2953
Thomas WolfersDonders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, The Netherlands.ORCID http://orcid.org/0000-0002-7693-0621
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Uli BrombergSystems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Christian BüchelSystems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Patricia ConrodDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience King's College London, London, UK.
Tahmine FadaiSystems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vincent FrouinNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0001-9360-6623
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Philip A SpechlerDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Yvonne GrimmerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bernd IttermannBiomedical Magnetic Resonance, Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
Viola KappelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Humboldt University, Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette; and Maison de Solenn, Paris, France.
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-5619-1123
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Betteke van NoortDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Humboldt University, Berlin, Germany.ORCID http://orcid.org/0000-0002-9768-3383
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-0452-2450
Jani PenttiläDepartment of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, Lahti, Finland.ORCID http://orcid.org/0000-0001-6499-9376
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
Erin Burke QuinlanCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2927-1632
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Argyris StringarisDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Maren StruveDepartment of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0003-1311-0631
Ilya M VeerDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2790-7281
Ole A AndreassenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Ingrid AgartzNORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Hervé LemaitreInstitut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin, Gif-sur-Yvette, France.
Edward D BarkerCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
John AshburnerWellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, UK.
Elisabeth BinderNeuroimaging, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7088-6618
Jan BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Andre MarquandDonders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, The Netherlands.
Trevor W RobbinsDepartment of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0642-5977
Gunter SchumannCentre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK. gunter.schumann@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7740-6469
IMAGEN Consortium
Funding
Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759
Abstract
Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.
Indexed as
Executive FunctionAdolescentAnisotropyAnxietyAttention Deficit Disorder with HyperactivityBrainCorrelation of DataDepressionDepressive DisorderDiffusion Tensor ImagingFemaleFunctional NeuroimagingGray MatterHumansMagnetic Resonance ImagingMale
Identifiers
PMID
31591521What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.