ArticleMolecular psychiatry2020
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
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72citing papers in PubMed, 2 pooled it
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Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics · 2021Pooled it
- Neuropsychiatry genetics in Africa.Nature communications · 2026Review
- Short-term longitudinal changes in metabolic and cardiac parameters in inpatients with schizophrenia: the role of age and sex.European archives of psychiatry and clinical neuroscience · 2026Article
- Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder.Translational psychiatry · 2026Article
- Article
- Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Unraveling the enigma: Post-translational modifications in psychiatric disorders and their regulatory mechanisms.Journal of translational internal medicine · 2026Article
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- Article
- Investigating the polygenic relationship between heavy cannabis use and schizophrenia in the All of Us Research Program.Psychological medicine · 2025Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.Psychological medicine · 2025Article
- Cognitive and Global Morphometry Trajectories as Predictors of Youth Persistent Distressing Psychotic-Like Experiences.Nature. Mental health · 2025Article
- The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO): building local capacity in genomics and bioinformatics.Communications biology · 2025Article
- Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study.BMC psychiatry · 2025Article
- Differential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals.Schizophrenia research · 2025Article
- Diversifying Psychiatric Genomics: Globally Inclusive Strategies Toward Health Equity.The Psychiatric clinics of North America · 2025Review
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population.Translational psychiatry · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
60 authors.
Tim B Bigdeli *Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA. tim.bigdeli@downstate.edu.
Giulio Genovese *Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Penelope GeorgakopoulosInstitute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Roseann E PetersonDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Conrad O IyegbeDepartment of Psychosis Studies, King's College London, London, UK.
Helena MedeirosInstitute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Jorge ValderramaDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Eric D AchtyesCherry Health and Michigan State University College of Human Medicine, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-8939-1535
Roman KotovDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Eli A StahlDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.ORCID http://orcid.org/0000-0002-1192-0561
Colony AbbottDepartment of Psychiatry & Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Maria Helena AzevedoInstitute of Medical Psychology, Faculty of Medicine, University of Coimbra, Coimbra, PT, Portugal.
Richard A BelliveauStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth BevilacquaBeacon Health Options, Boston, MA, USA.
Evelyn J BrometDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
William ByerleyDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Celia Barreto CarvalhoFaculty of Social and Human Sciences, University of Azores, Ponta Delgada, Portugal.ORCID http://orcid.org/0000-0003-4453-8139
Sinéad B ChapmanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lynn E DeLisiVA Boston Healthcare System, Brockton, MA, USA.
Ashley L DumontStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Colm O'DushlaineStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Oleg V EvgrafovInstitute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Laura J FochtmannDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Diane GageStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
James L KennedyNeurogenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Becky KinkeadDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Antonio MacedoInstitute of Medical Psychology, Faculty of Medicine, University of Coimbra, Coimbra, PT, Portugal.ORCID http://orcid.org/0000-0003-2180-2718
Jennifer L MoranStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Christopher P MorleyDepartment of Public Health and Preventive Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Mantosh J DewanDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY, USA.
James NemeshStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Shaun M PurcellStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jeffrey J RakofskyDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Edward M ScolnickStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Brooke M SklarDepartment of Psychiatry & Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Pamela SklarDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334
Patrick F SullivanDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-6619-873X
Fabio MacciardiDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-0537-4266
Stephen R MarderDepartment of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-0288-309X
Ruben C GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA, USA.
David L BraffDepartment of Psychiatry, University of California, La Jolla, San Diego, CA, USA.
Consortium on the Genetics of Schizophrenia (COGS) Investigators
Humberto NicoliniCarracci Medical Group, Mexico City, MX, Mexico.
Michael A EscamillaDepartment of Psychiatry, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Marquis P VawterDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Janet L SobellDepartment of Psychiatry & Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Dolores MalaspinaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.
Douglas S LehrerDepartment of Psychiatry, Wright State University, Dayton, OH, USA.
Peter F BuckleySchool of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Mark H RapaportDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
James A KnowlesInstitute for Genomic Health, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Genomic Psychiatry Cohort (GPC) Consortium
Ayman H FanousDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Michele T Pato *Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Steven A McCarroll *Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Carlos N Pato *Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Funding
African Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MGenomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0MLatino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1MThe Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0MTrajectories of Aging in Psychotic Disorders Over 27 YearsR01MH110434 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KOTOV, ROMAN I · 2016 to 2020
$4.5MA Genome-Wide Association Study of SchizophreniaU01MH079469 · NIMH · NORTHSHORE UNIVERSITY HEALTHSYSTEM · PI GEJMAN, PABLO V. · 2007 to 2009
$4.4MThe Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2MThe Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1MGenetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7MThe Genetics of Endophenotypes and SchizophreniaR01MH065707 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2013
$3.6MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060879 · NIMH · WASHINGTON UNIVERSITY · PI CLONINGER, C. ROBERT · 1999 to 2006
$2.7MNIDA NIH HHS K01 DA037914NIMH NIH HHS K01 MH113848NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01 MH065562NIMH NIH HHS R01 MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01 MH065588NIMH NIH HHS R01 MH065707NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH086135NIMH NIH HHS R01 MH094320NIMH NIH HHS R01 MH094398NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH110434NIMH NIH HHS R01 MH123451NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046289NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470
Abstract
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples with African ancestry with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded seven newly genome-wide significant loci, and we identified an additional eight loci by incorporating the results from samples with Latino ancestry. Leveraging population differences in patterns of linkage disequilibrium, we achieve improved fine-mapping resolution at 22 previously reported and 4 newly significant loci. Polygenic risk score profiling revealed improved prediction based on trans-ancestry meta-analysis results for admixed African (Nagelkerke's R
Indexed as
Genome-Wide Association StudyBlack PeopleFemaleGenetic LociGenetic Predisposition to DiseaseHispanic or LatinoHumansMalePolymorphism, Single NucleotideSchizophrenia
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